Midbrain dopaminergic neurons project to and modulate multiple highly interconnected modules of the basal ganglia, limbic system, and frontal cortex. Dopamine regulates behaviors associated with action selection in the striatum, reward in the nucleus accumbens (NAc), emotional processing in the amygdala, and executive functioning in the medial prefrontal cortex (mPFC). The multifunctionality of dopamine likely occurs at the individual synapses, with varied levels of phasic dopamine release acting on different receptor populations. This study aimed to characterize specific aspects of stimulation-evoked phasic dopamine transmission, beyond simple dopamine release, using in vivo fixed potential amperometry with carbon fiber recording microelectrodes positioned in either the dorsal striatum, NAc, amygdala, or mPFC of anesthetized mice. To summarize results, the present study found that the striatum and NAc had increased stimulation-evoked phasic dopamine release, faster dopamine uptake (leading to restricted dopamine diffusion), weaker autoreceptor functioning, greater supply levels of available dopamine, and increased dopaminergic responses to DAT blockade compared to the amygdala and mPFC. Overall, these findings indicate that phasic dopamine may have different modes of communication between striatal and corticolimbic regions, with the first being profuse in concentration, rapid, and synaptically confined and the second being more limited in concentration but longer lasting and spatially dispersed. An improved understanding of regional differences in dopamine transmission can lead to more efficient treatments for disorders related to dopamine dysfunction.

中文翻译：

---

比较纹状体、伏隔核、杏仁核和内侧前额皮质的阶段性多巴胺动力学。


中脑多巴胺能神经元投射并调节基底神经节、边缘系统和额叶皮层的多个高度互连的模块。多巴胺调节与纹状体的动作选择、伏隔核 (NAc) 的奖励、杏仁核的情绪处理以及内侧前额叶皮层 (mPFC) 的执行功能相关的行为。多巴胺的多功能性可能发生在各个突触处，不同水平的阶段性多巴胺释放作用于不同的受体群体。本研究旨在表征刺激诱发的阶段性多巴胺传递的具体方面，而不仅仅是简单的多巴胺释放，使用体内固定电位安培法和位于麻醉小鼠背侧纹状体、NAc、杏仁核或 mPFC 的碳纤维记录微电极。总而言之，本研究发现纹状体和 NAc 增加了刺激诱发的阶段性多巴胺释放、更快的多巴胺摄取（导致多巴胺扩散受限）、自身受体功能较弱、可用多巴胺的供应水平更高以及对 DAT 的多巴胺能反应增加与杏仁核和 mPFC 相比，封锁。总体而言，这些发现表明，阶段性多巴胺在纹状体和皮质边缘区域之间可能具有不同的通讯模式，第一种是浓度丰富、快速且突触受限的，第二种是浓度更有限但持续时间更长且空间分散的。更好地了解多巴胺传递的区域差异可以更有效地治疗与多巴胺功能障碍相关的疾病。