BACKGROUND Clinical information of Elizabethkingia meningoseptica (EM) bacteremia in intensive care unit (ICU) patients is limited and the impact on outcomes uncertain. The aim of this study was to investigate the clinical features and impact of EM bacteremia compared to other glucose non-fermenting Gram-negative bacilli (GNF-GNB) bacteremia in ICU patients. METHODS This retrospective cohort study enrolled 70 patients who developed GNF-GNB bacteremia after ICU admission, including 19 cases of EM bacteremia (19/70, 27.1%). The main outcome measure was in-hospital mortality. RESULTS The patients with EM bacteremia had a lower rate of appropriate antibiotic therapy (15.8% vs. 62.7%, p < 0.001) and a longer time to appropriate antibiotic therapy (76.8 ± 46.4 vs. 35.1 ± 38.7 h, p < 0.001), but with a less severity in acute physiology and chronic health evaluation (APACHE) II score and shock status (p < 0.05) at the onset of bacteremia, compared to those with non-EM bacteremia. The in-hospital mortality between those with EM bacteremia and non-EM bacteremia was similar (63.2% vs. 51.0%, p = 0.363). However, primary bacteremia was more frequently noted in EM compared with non-EM group (57.9% vs. 25.5%, p = 0.011), and odds ratio 4.294 (95% confidence interval 1.292-14.277, p = 0.017) in multivariate regression analysis. CONCLUSION Among the patients with GNF-GNB bacteremia, the numbers of the cases with primary bacteremia and inappropriate therapy were significantly more in EM group than those in non-EM group.

中文翻译：

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成人ICU患者脑膜炎伊丽莎白女王与其他葡萄糖非发酵性革兰氏阴性菌菌血症之间的临床特征和结局比较。

背景技术重症监护病房（ICU）患者的脑膜炎伊丽莎白病菌（EM）菌血症的临床信息有限，并且对预后的影响尚不确定。这项研究的目的是调查与ICU患者其他非葡萄糖发酵型革兰阴性杆菌（GNF-GNB）菌血症相比，EM菌血症的临床特征和影响。方法这项回顾性队列研究纳入了70例ICU入院后发生GNF-GNB菌血症的患者，包括19例EM菌血症（19 / 70，27.1％）。主要结局指标是院内死亡率。结果EM菌血症患者接受适当抗生素治疗的比率较低（15.8％比62.7％，p <0.001），接受适当抗生素治疗的时间更长（76.8±46.4 vs. 35.1±38.7 h，p <0.001），但与非EM菌血症相比，菌血症发作时的急性生理和慢性健康评估（APACHE）II评分和休克状态严重程度较低（p <0.05）。EM菌血症和非EM菌血症患者的院内死亡率相似（63.2％对51.0％，p = 0.363）。然而，在多元回归分析中，与非EM组相比，EM中原发菌血症的发生率更高（57.9％比25.5％，p = 0.011），比值比为4.294（95％置信区间1.292-14.277，p = 0.017）。 。结论在GNF-GNB菌血症患者中，EM组的原发菌血症和不适当治疗的人数明显多于非EM组。与非EM菌血症相比。EM菌血症和非EM菌血症患者的院内死亡率相似（63.2％对51.0％，p = 0.363）。然而，在多元回归分析中，与非EM组相比，EM中原发菌血症的发生率更高（57.9％比25.5％，p = 0.011），比值比为4.294（95％置信区间1.292-14.277，p = 0.017）。 。结论在GNF-GNB菌血症患者中，EM组的原发菌血症和不适当治疗的人数明显多于非EM组。与非EM菌血症相比。EM菌血症和非EM菌血症患者的院内死亡率相似（63.2％对51.0％，p = 0.363）。然而，在多元回归分析中，与非EM组相比，EM中原发菌血症的发生率更高（57.9％比25.5％，p = 0.011），比值比为4.294（95％置信区间1.292-14.277，p = 0.017）。 。结论在GNF-GNB菌血症患者中，EM组的原发菌血症和不适当治疗的人数明显多于非EM组。多元回归分析为294（95％置信区间1.292-14.277，p = 0.017）。结论在GNF-GNB菌血症患者中，EM组的原发菌血症和不适当治疗的人数明显多于非EM组。多元回归分析为294（95％置信区间1.292-14.277，p = 0.017）。结论在GNF-GNB菌血症患者中，EM组的原发菌血症和不适当治疗的人数明显多于非EM组。