Periprosthetic joint infection following joint arthroplasty surgery is one of the most feared complications. The key to successful revision surgery for periprosthetic joint infections, regardless of treatment strategy, is a thorough deep debridement. In an attempt to limit antimicrobial and disinfectant use, there has been increasing interest in the use of acetic acid as an adjunct to debridement in the management of periprosthetic joint infections. However, its effectiveness in the eradication of established biofilms following clinically relevant treatment times has not been established. Using an in vitro biofilm model, this study aimed to establish the minimum biofilm eradication concentration (MBEC) of acetic acid following a clinically relevant treatment time.

中文翻译：

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乙酸在治疗假体周围感染中的生物膜清除活性。

关节置换手术后的假体周围感染是最可怕的并发症之一。无论治疗策略如何，假体周围感染翻修手术成功的关键是彻底的深度清创。为了限制抗微生物剂和消毒剂的使用，人们越来越关注使用醋酸作为清创术治疗假体周围感染的辅助手段。然而，尚未确定其在临床相关治疗时间后根除已建立的生物膜的有效性。本研究使用体外生物膜模型，旨在确定在临床相关治疗时间后乙酸的最低生物膜清除浓度 (MBEC)。