S100A8/A9 and S100A12 are released from activated monocytes and granulocytes and act as proinflammatory endogenous toll-like receptor (TLR)4-ligands. S100 serum concentrations correlate with disease activity, both during local and systemic inflammatory processes. In some autoinflammatory diseases such as familial Mediterranean fever (FMF) or systemic juvenile idiopathic arthritis (SJIA), dysregulation of S100 release may be involved in the pathogenesis. Moreover, S100 serum levels are a valuable supportive tool in the diagnosis of SJIA in fever of unknown origin. Furthermore, S100 levels can be used to monitor disease activity to subclinical level, as their serum concentrations decrease with successful treatment.

中文翻译：

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S100蛋白在自身炎症性疾病发病机制和监测中的作用

S100A8/A9 和 S100A12 从活化的单核细胞和粒细胞中释放出来，充当促炎性内源性 Toll 样受体 (TLR)4-配体。S100 血清浓度与局部和全身炎症过程中的疾病活动相关。在一些自身炎症性疾病中，如家族性地中海热 (FMF) 或全身性幼年特发性关节炎 (SJIA)，S100 释放失调可能参与发病机制。此外，S100 血清水平是诊断不明原因发热的 SJIA 的有价值的支持工具。此外，S100 水平可用于监测亚临床水平的疾病活动，因为它们的血清浓度随着治疗成功而降低。