Low-magnitude, high-frequency vibration has stimulated osteogenesis in mesenchymal stem cells when these cells were cultured in certain types of three-dimensional environments. However, results of osteogenesis are conflicting with some reports showing no effect of vibration at all. A large number of vibration studies using three-dimensional scaffolds employ scaffolds derived from natural sources. Since these natural sources potentially have inherent biochemical and microarchitectural cues, we explored the effect of low-magnitude, high-frequency vibration at low, medium, and high accelerations when mesenchymal stem cells were encapsulated in poly(ethylene glycol) diacrylate microspheres. Low and medium accelerations enhanced osteogenesis in mesenchymal stem cells while high accelerations inhibited it. These studies demonstrate that the isolated effect of vibration alone induces osteogenesis.

中文翻译：

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低强度，高频振动对聚乙二醇微胶囊间充质干细胞的影响。

当在某些类型的三维环境中培养这些细胞时，低强度，高频振动刺激了它们之间的成骨作用。但是，成骨的结果与一些报告完全没有振动的影响相矛盾。使用三维脚手架的大量振动研究都采用了自然来源的脚手架。由于这些天然来源可能具有固有的生化和微体系结构线索，因此我们探讨了将间充质干细胞封装在聚（乙二醇）二丙烯酸酯微球中时低幅度，高频振动在低，中和高加速度下的作用。低速和中速加速增强了间充质干细胞的成骨作用，而高速加速则抑制了它。