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Microbiological features, clinical characteristics and outcomes of infective endocarditis in adults with and without hemodialysis: A 10-year retrospective study in Northern Taiwan.
Journal of Microbiology, Immunology and Infection ( IF 4.5 ) Pub Date : 2018-09-05 , DOI: 10.1016/j.jmii.2018.08.013 Chien-Yao Wang,Yung-Chih Wang,Ya-Sung Yang,Chan-Yuan Chang,Kuan-Yu Chen,Jiun-Ji Lai,Jung-Chung Lin,Feng-Yee Chang
Journal of Microbiology, Immunology and Infection ( IF 4.5 ) Pub Date : 2018-09-05 , DOI: 10.1016/j.jmii.2018.08.013 Chien-Yao Wang,Yung-Chih Wang,Ya-Sung Yang,Chan-Yuan Chang,Kuan-Yu Chen,Jiun-Ji Lai,Jung-Chung Lin,Feng-Yee Chang
BACKGROUND/PURPOSES
Infective endocarditis (IE) is an important cause of morbidity and mortality in hemodialysis (HD) patients. Data on the differences in the microbiological features as well as clinical characteristics and outcomes of HD and non-HD patients with IE are limited.
METHODS
Medical records of patients (aged over 20 years) with IE were retrospectively reviewed from January 2008 to June 2017 in a tertiary care center in Northern Taiwan. Those with definite or possible IE were included in the study. The clinical characteristics, microbiological results, echocardiographic findings and outcomes of patients were analyzed.
RESULTS
Of the 183 patients with definite or possible IE, 47 had undergone HD and 136 had not. Advanced age (67.3 vs. 61.5 years, p = 0.027), more female gender (51.1% vs. 33.8%, p = 0.036), comorbidities (a high Charlson comorbidity index, 8.17 vs. 4.21, p < 0.001), diabetes mellitus (68.1% vs. 35.3%, p < 0.001), and hypertension (85.1% vs. 53.7%, p < 0.001) were commonly observed in HD patients than in non-HD patients. The yield rate of the blood cultures was higher in HD group than in non-HD group (89.4% vs. 72.8%, p = 0.02). The proportion of methicillin-resistant Staphylococcus aureus was significantly higher in HD group than in non-HD group (31.9% vs. 5.9%, p < 0.001). HD patients versus non-HD patients had higher cardiac complication rates (38.3% vs. 14%, p < 0.001).
CONCLUSION
Advanced age, sex (female), comorbidities, diabetes mellitus, and hypertension were more common in HD patients than in non-HD patients with IE. HD patients had higher proportion of methicillin-resistant S. aureus and cardiac complication rates than non-HD patients with IE. Culture-negative IE was more common in non-HD patients.
更新日期：2020-04-22
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