The definition of priority substances (PS) according to the Water Framework Directive (WFD) helped to remove many of these chemicals from the market and to reduce their concentrations in the European water bodies. However, it could not prevent that many of these chemicals have been replaced by others with similar risks. Today, monitoring of the PS-based chemical status according to WFD covers only a tiny fraction of toxic risks, extensively ignores mixture effects and lacks incentives and guidance for abatement. Thus, we suggest complement this purely status-related approach with more holistic and solution-oriented monitoring, which at the same time helps to provide links to the ecological status. Major elements include (1) advanced chemical screening techniques supporting mixture risk assessment and unraveling of source-related patterns in complex mixtures, (2) effect-based monitoring for the detection of groups of chemicals with similar effects and the establishment of toxicity fingerprints, (3) effect-directed analysis of drivers of toxicity and (4) to translate chemical and toxicological fingerprints into chemical footprints for prioritization of management measures. The requirement of more holistic and solution-oriented monitoring of chemical contamination is supported by the significant advancement of appropriate monitoring tools within the last years. Non-target screening technology, effect-based monitoring and basic understanding of mixture assessment are available conceptually and in research but also increasingly find their way into practical monitoring. Substantial progress in the development, evaluation and demonstration of these tools, for example, in the SOLUTIONS project enhanced their acceptability. Further advancement, integration and demonstration, extensive data exchange and closure of remaining knowledge gaps are suggested as high priority research needs for the next future to bridge the gap between insufficient ecological status and cost-efficient abatement measures.

中文翻译：

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旨在对欧洲水体的化学状态进行全面且面向解决方案的监视：如何支持欧盟的无毒环境战略？

根据《水框架指令》（WFD）对优先物质（PS）的定义有助于将许多此类化学物质从市场上清除，并降低了它们在欧洲水域中的浓度。但是，这无法阻止许多此类化学物质被具有类似风险的其他化学物质所替代。如今，根据WFD监测基于PS的化学状态仅涵盖了极小部分的毒性风险，广泛忽略了混合物的影响，并且缺乏减少污染的诱因和指导。因此，我们建议通过更全面和面向解决方案的监视来补充这种与状态完全相关的方法，同时有助于提供与生态状态的联系。主要内容包括（1）先进的化学筛选技术，可支持混合物风险评估和复杂混合物中与源相关的模式的揭示；（2）基于效果的监测，以检测具有相似效果的化学品组，并建立毒性指纹，（ 3）对毒性驱动因素进行效果导向的分析，以及（4）将化学和毒理学指纹转换为化学足迹，以便对管理措施进行优先排序。过去几年中，适当的监控工具取得了巨大的进步，这支持了对化学污染进行更全面和面向解决方案的监控的要求。非目标筛选技术 基于效果的监测和对混合物评估的基本了解在概念上和研究中都可以找到，但也越来越多地应用于实际监测中。例如，在SOLUTIONS项目中，这些工具的开发，评估和演示取得了实质性进展，提高了它们的接受度。提出进一步的发展，整合和示范，广泛的数据交换以及缩小剩余的知识差距，这是对下一个未来的高度优先研究需求，以弥合生态状况不足和成本有效的减排措施之间的差距。