1-Aminobenzotriazole (1-ABT) is a pan-specific, mechanism-based inactivator of the xenobiotic metabolizing forms of cytochrome P450 in animals, plants, insects, and microorganisms. It has been widely used to investigate the biological roles of cytochrome P450 enzymes, their participation in the metabolism of both endobiotics and xenobiotics, and their contributions to the metabolism-dependent toxicity of drugs and chemicals. This review is a comprehensive evaluation of the chemistry, discovery, and use of 1-aminobenzotriazole in these contexts from its introduction in 1981 to the present.

中文翻译：

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1-氨基苯并三唑：基于机制的细胞色素 P450 抑制剂和细胞色素 P450 生物学探针。


1-氨基苯并三唑 (1-ABT) 是动物、植物、昆虫和微生物中细胞色素 P450 外源代谢形式的泛特异性、基于机制的灭活剂。它已被广泛用于研究细胞色素 P450 酶的生物学作用、它们在内生物质和外源物质代谢中的参与，以及它们对药物和化学品代谢依赖性毒性的贡献。本综述对 1-氨基苯并三唑从 1981 年推出至今的化学、发现和使用进行了全面评估。