BACKGROUND Irritable bowel syndrome with constipation (IBS-C) is a representative psychosomatic disorder. Several pathophysiological factors have been linked to IBS symptoms such as the modulation of gastrointestinal motility, visceral hypersensitivity, dysregulation of the gut-brain axis, genetic and environmental factors, sequelae of infection, and psychosocial disorders. It is likely that biopsychosocial aspects of IBS-C underlie its gender and age effects. However, the influence of each symptom of IBS-C by gender and age is not well understood. We hypothesized that the expression rate of each IBS-C symptom in females and in subjects aged 20-49 years was higher than that of subjects who were male and aged 50-79 years. METHODS We conducted an internet survey of 30,000 adults from the general Japanese population. IBS-C subjects were asked to answer a questionnaire on the degree of anxiety, thoughts about bowel habits, and their dominant gastrointestinal symptoms together with exacerbation factors. The correlation between gender and age and IBS-C symptoms was analyzed. RESULTS When analyzed by gender, the expression rate of abdominal discomfort, abdominal distention, and abdominal fullness was significantly higher in female than male IBS-C subjects (66.5% vs. 58.7%, p < 0.05; 54.7% vs. 43.6%, p < 0.01; 18.9% vs. 9.6%, p < 0.01, respectively). When analyzed by age, the expression rate of abdominal distention and abdominal pain was significantly higher among IBS-C subjects aged 20-49 years than those aged 50-79 years (55.7% vs. 46.8%, p < 0.05; 36.6% vs. 20.6%, p < 0.001, respectively). In contrast, there was no gender or age differences with regard to the most common and bothersome symptom (abdominal bloating) among IBS-C subjects. CONCLUSIONS The expression rate of some IBS-C symptoms was higher among females and those aged 20-49 years than males and those aged 50-79 years, respectively. It is important to understand the impact of symptoms by gender and age to evaluate the pathology of IBS-C from a biopsychosocial perspective. TRIAL REGISTRATION Although this survey was an anonymous internet survey, we obtained informed consent for the study as an online response. The disclosure of this study was approved by the Ethics Committee of Tohoku University Graduate School of Medicine (approval number: 2015-1-405).

中文翻译：

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日本便秘型肠易激综合征 (IBS-C) 受试者性别和年龄对症状的影响：一项基于人群的大型互联网调查。

背景技术伴有便秘的肠易激综合征（IBS-C）是一种代表性的心身疾病。一些病理生理因素与 IBS 症状有关，例如胃肠动力的调节、内脏超敏反应、肠-脑轴的失调、遗传和环境因素、感染后遗症和社会心理障碍。IBS-C 的生物心理社会方面可能是其性别和年龄影响的基础。然而，IBS-C 的每种症状对性别和年龄的影响尚不清楚。我们假设女性和 20-49 岁受试者中每种 IBS-C 症状的表达率高于男性和 50-79 岁受试者。方法 我们对来自日本普通人群的 30,000 名成年人进行了互联网调查。IBS-C 受试者被要求回答一份关于焦虑程度、对排便习惯的想法、主要胃肠道症状以及恶化因素的问卷。分析性别和年龄与IBS-C症状的相关性。结果按性别分析，女性IBS-C患者腹部不适、腹胀、腹胀的表达率显着高于男性（66.5% vs. 58.7%，p < 0.05；54.7% vs. 43.6%，p < 0.01；分别为 18.9% 和 9.6%，p < 0.01）。按年龄分析，20~49岁IBS-C受试者腹胀、腹痛的表达率明显高于50~79岁（55.7% vs. 46.8%，p < 0.05；36.6% vs. 20.6%，p < 0.001，分别）。相比之下，IBS-C 受试者最常见和最烦人的症状（腹胀）没有性别或年龄差异。结论女性和20~49岁人群IBS-C部分症状的表达率分别高于男性和50~79岁人群。从生物心理社会的角度评估 IBS-C 的病理学，了解不同性别和年龄的症状的影响是很重要的。试验注册 虽然这项调查是一项匿名的互联网调查，但我们作为在线回复获得了该研究的知情同意书。本研究的公开经东北大学医学研究生院伦理委员会批准（批准号：2015-1-405）。结论女性和20~49岁人群IBS-C部分症状的表达率分别高于男性和50~79岁人群。从生物心理社会的角度评估 IBS-C 的病理学，了解不同性别和年龄的症状的影响是很重要的。试验注册 虽然这项调查是一项匿名的互联网调查，但我们作为在线回复获得了该研究的知情同意书。本研究的公开经东北大学医学研究生院伦理委员会批准（批准号：2015-1-405）。结论女性和20~49岁人群IBS-C部分症状的表达率分别高于男性和50~79岁人群。从生物心理社会的角度评估 IBS-C 的病理学，了解不同性别和年龄的症状的影响是很重要的。试验注册 虽然这项调查是一项匿名的互联网调查，但我们作为在线回复获得了该研究的知情同意书。本研究的公开经东北大学医学研究生院伦理委员会批准（批准号：2015-1-405）。试验注册 虽然这项调查是一项匿名的互联网调查，但我们作为在线回复获得了该研究的知情同意书。本研究的公开经东北大学医学研究生院伦理委员会批准（批准号：2015-1-405）。试验注册 虽然这项调查是一项匿名的互联网调查，但我们作为在线回复获得了该研究的知情同意书。本研究的公开经东北大学医学研究生院伦理委员会批准（批准号：2015-1-405）。