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Evaluation of two collagen conduits and autograft in rabbit sciatic nerve regeneration with quantitative magnetic resonance DTI, electrophysiology, and histology.
European Radiology Experimental ( IF 3.7 ) Pub Date : 2018-08-08 , DOI: 10.1186/s41747-018-0049-2 Tina Jeon 1 , Emil S Vutescu 2 , Eliana B Saltzman 2 , Jordan C Villa 2 , Scott W Wolfe 2 , Steve K Lee 2 , Joseph H Feinberg 3 , Sarah L Pownder 1 , Jonathan P Dyke 4 , Darryl B Sneag 1
中文翻译:
用定量磁共振 DTI、电生理学和组织学评估兔坐骨神经再生中的两种胶原蛋白导管和自体移植物。
更新日期:2018-08-08
European Radiology Experimental ( IF 3.7 ) Pub Date : 2018-08-08 , DOI: 10.1186/s41747-018-0049-2 Tina Jeon 1 , Emil S Vutescu 2 , Eliana B Saltzman 2 , Jordan C Villa 2 , Scott W Wolfe 2 , Steve K Lee 2 , Joseph H Feinberg 3 , Sarah L Pownder 1 , Jonathan P Dyke 4 , Darryl B Sneag 1
Affiliation
Background
We compared different surgical techniques for nerve regeneration in a rabbit sciatic nerve gap model using magnetic resonance diffusion tensor imaging (DTI), electrophysiology, limb function, and histology.Methods
A total of 24 male New Zealand white rabbits were randomized into three groups: autograft (n = 8), hollow conduit (n = 8), and collagen-filled conduit (n = 8). A 10-mm segment of the rabbit proximal sciatic nerve was cut, and autograft or collagen conduit was used to bridge the gap. DTI on a 3-T system was performed preoperatively and 13 weeks after surgery using the contralateral, nonoperated nerve as a control.Results
Overall, autograft performed better compared with both conduit groups. Differences in axonal diameter were significant (autograft > hollow conduit > collagen-filled conduit) at 13 weeks (autograft vs. hollow conduit, p = 0.001, and hollow conduit vs. collagen-filled conduit, p < 0.001). Significant group differences were found for axial diffusivity but not for any of the other DTI metrics (autograft > hollow conduit > collagen-filled conduit) (autograft vs. hollow conduit, p = 0.001 and hollow conduit vs. collagen-filled conduit, p = 0.021). As compared with hollow conduit (autograft > collagen-filled conduit > hollow conduit), collagen-filled conduit animals demonstrated a nonsignificant increased maximum tetanic force.Conclusions
Autograft-treated rabbits demonstrated improved sciatic nerve regeneration compared with collagen-filled and hollow conduits as assessed by histologic, functional, and DTI parameters at 13 weeks.中文翻译:
用定量磁共振 DTI、电生理学和组织学评估兔坐骨神经再生中的两种胶原蛋白导管和自体移植物。