New organic salts were synthesized by quaternizing 1,10-phenanthroline using 1-bromotetradecane. The first step yielded an organic salt of formula [C₂₆H₃₇N₂]Br. Anion exchange reaction using Li[(CF₃SO₂)₂N] resulted in a more stable salt of formula [C₂₆H₃₇N₂][(CF₃SO₂)₂N]. The organic salts were investigated by spectrometry (¹H, ¹³C, ¹⁹F NMR, X-ray photoelectron spectroscopy (XPS), UV-Vis, and matrix-assisted laser desorption/ionization mass spectroscopy (MALDI MS), CHNSBr elemental analysis, and thermal analysis (TGA and DSC). The thermal characterization showed the melting and decomposition points of [C₂₆H₃₇N₂][(CF₃SO₂)₂N] to be 48°C and 290°C, respectively, which indicates it is an ionic liquid with large liquidus range. The biological activities of the salts were investigated against two Gram-positive (Staphylococcus aureus and Streptococcus pyogenes) and two Gram-negative (Escherichia coli and Klebsiella pneumoniae) bacteria, and they are found to be active against all of them. They were compared with [Cu(1,10-phenanthroline)₂Cl]Cl. They are found more active against the Gram-negative bacteria. The salts demonstrated minimum inhibitory concentration as low as 50 µg/L. These results suggest the synthesized salts can be considered as a better alternative to certain transition metal complex drugs. This minimizes the concern of introducing metal ions into the organism.

中文翻译：

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合成用于生物应用的N-十四烷基1,10-菲咯啉基新盐。

通过使用1-溴十四烷季铵化1,10-菲咯啉来合成新的有机盐。第一步得到式[C ₂₆ H ₃₇ N ₂ ] Br的有机盐。使用Li [（CF ₃ SO ₂）₂ N]进行阴离子交换反应得到了更稳定的式[C ₂₆ H ₃₇ N ₂ ] [（CF ₃ SO ₂）₂ N]盐。通过分光光度法（¹ H，¹³ C，¹⁹F NMR，X射线光电子能谱（XPS），UV-Vis和基质辅助激光解吸/电离质谱（MALDI MS），CHNSBr元素分析和热分析（TGA和DSC）。热特性表明，[C ₂₆ H ₃₇ N ₂ ] [（CF ₃ SO ₂）₂ N]的熔点和分解点分别为48℃和290℃，这表明它是具有大液相线的离子液体。范围。研究了盐对两种革兰氏阳性（金黄色葡萄球菌和化脓性链球菌）和两种革兰氏阴性（大肠杆菌和肺炎克雷伯菌）的生物学活性。）细菌，发现它们对所有细菌都有活性。将它们与[Cu（1,10-菲咯啉）₂ Cl] Cl进行比较。发现它们对革兰氏阴性细菌更具活性。盐显示出最低抑制浓度低至50  µg / L。这些结果表明，合成盐可以被认为是某些过渡金属络合物药物的更好替代品。这最小化了将金属离子引入生物体的担忧。