Manganese plays multiple role in many biological redox reactions in which it exists in different oxidation states from Mn(II) to Mn(IV). Among them the high-valent manganese-oxo intermediate plays important role in the activity of certain enzymes and lessons from the natural system provide inspiration for new developments of artificial systems for a sustainable energy supply and various organic conversions. This review describes recent advances and key lessons learned from the nature on high-valent Mn-oxo intermediates. Also we focus on the elemental science developed from the natural system, how the novel strategies are realised in nano particles and molecular sites at heterogeneous and homogeneous reaction conditions respectively. Finally, perspectives on the utilisation of the high-valent manganese-oxo species towards other organic reactions are proposed.

中文翻译：

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高价锰-氧代中间体参与氧化反应：在自然，纳米和分子系统中的实现。

锰在许多生物氧化还原反应中扮演多种角色，其中锰以不同的氧化态（从锰（Ⅱ）到锰（Ⅳ））存在。其中高价锰-氧代中间体在某些酶的活性中起重要作用，而来自天然系统的经验教训则为可持续能源供应和各种有机转化的人工系统的新发展提供了灵感。这篇综述描述了从自然界中有关高价Mn-氧代中间体的最新进展和主要经验教训。此外，我们还将重点关注从自然系统发展而来的元素科学，以及如何分别在异质和均相反应条件下在纳米粒子和分子位点实现新策略。最后，