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Immunohistochemistry in the Detection of Early Myocardial Infarction
Applied Immunohistochemistry & Molecular Morphology ( IF 1.3 ) Pub Date : 2020-02-01 , DOI: 10.1097/pai.0000000000000688
Rosario Barranco 1 , Francesco Ventura
Affiliation  

The postmortem diagnosis of acute myocardial infarction is one of the main problems in forensic practice, especially in cases in which death occurs soon after (from minutes to a few hours) the onset of the ischemic damage. Several authors have highlighted the possibility to overcome the limits of conventional histology in this diagnosis by utilizing immunohistochemistry. In the present research, we examined over 30 scientific studies and picked out over 20 main immunohistochemical antigens analyzed with a view to enabling the rapid diagnosis of early myocardial infarction. The aim of our review was to examine and summarize all the principal markers studied to date and also to consider their limitations, including protein alteration because of cadaveric autolysis and putrefaction.

中文翻译:

免疫组化检测早期心肌梗死

急性心肌梗塞的死后诊断是法医实践中的主要问题之一,尤其是在缺血性损伤发生后不久(几分钟到几小时)死亡的情况下。几位作者强调了通过利用免疫组织化学来克服该诊断中传统组织学局限性的可能性。在目前的研究中,我们审查了 30 多项科学研究,挑选了 20 多种主要的免疫组织化学抗原进行分析,以期能够快速诊断早期心肌梗塞。我们审查的目的是检查和总结迄今为止研究的所有主要标志物,并考虑它们的局限性,包括由于尸体自溶和腐败导致的蛋白质改变。
更新日期:2020-02-01
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