Dioxin and dioxin-like compounds are known as a class of highly toxic and persistent environmental contaminants threatening human and animal health. In the present study, the protective effects of Coenzyme Q10 (CoQ10) and Resveratrol (RSV) against 2,3,7,8-TCDD, 1,2,3,7,8-PeCDD, 1,2,3,7,8,9-HxCDD, and 1,2,3,4,6,7,8,9-OCDD induced acute toxicity and measurement of oxidative stress were studied. Lethal doses of these chemicals were determined. Transheterozigot larvae of Drosophila melanogaster were treated using either dioxins (10 × 10-7 μg mL-1) or dioxins + CoQ10 (10 × 10-7 μg mL-1 + 150 μg mL-1) and dioxins + RSV (10 × 10-7 μg mL-1 + 100 μM). After dioxin treatment, antioxidant combination therapy with dioxins and CoQ10 or dioxins and RSV resulted in indicators of acute toxicity including a decrease in total oxidant status as compared to dioxins alone (p < 0.05). The combination treatment also produced a significant increase in total antioxidant status as compared to dioxins only (p < 0.05). Results indicate a potential role of dioxins for oxidative stress with acute toxicity and the protective performance of CoQ10 and RSV in the overall toxicity of dioxins including measuring oxidative stress.

中文翻译：

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辅酶Q10和白藜芦醇对多种二恶英诱导的果蝇变杂虫幼虫氧化应激的保护作用。

二恶英和类二恶英类化合物被认为是一类威胁人类和动物健康的剧毒持久性环境污染物。在本研究中，辅酶Q10（CoQ10）和白藜芦醇（RSV）对2,3,7,8-TCDD，1,2,3,7,8-PeCDD，1,2,3,7，研究了8,9-HxCDD和1,2,3,4,6,7,8,9-OCDD引起的急性毒性和氧化应激的测量。确定了这些化学物质的致死剂量。用二恶英（10×10-7μgmL-1）或二恶英+ CoQ10（10×10-7μgmL-1 + 150μgmL-1）和二恶英+ RSV（10×10）处理果蝇的变杂虫幼虫-7μgmL-1 + 100μM）。二恶英治疗后 与二恶英相比，二恶英和辅酶Q10或二恶英和RSV的抗氧化剂联合治疗可导致急性毒性的指标，包括总氧化剂状态的降低（p <0.05）。与仅二恶英相比，联合治疗还使总抗氧化剂状态显着提高（p <0.05）。结果表明，二恶英对具有急性毒性的氧化应激具有潜在的作用，并且辅酶Q10和RSV在包括测定氧化应激在内的二恶英的整体毒性中具有保护作用。