Pavement sealcoat products contain high concentrations of unsubstituted polycyclic aromatic hydrocarbons (PAHs), but the assessment of the potential toxicological impact is limited without the inclusion of PAH derivatives. This study determined the concentrations of 23 unsubstituted PAHs, 11 high molecular weight-PAHs (MW302-PAHs), and 56 PAH derivatives, including 10 methyl-PAHs (MPAHs), 10 heterocyclic-PAHs (Hetero-PAHs), 26 nitrated-PAHs (NPAHs), and 10 oxygenated-PAHs (OPAHs) in coal-tar and asphalt based sealcoat products and time point scrapes. Inclusion of MW302-PAHs resulted in an increase of 4.1-38.7% in calculated benzo[a]pyrene-carcinogenic equivalent (B[a]Peq) concentrations for the coal-tar based products. Increases in some NPAH and OPAH concentrations were measured after application, suggesting the possibility of photochemical transformation of unsubstituted PAHs. The Ames assay indicated that the asphalt based product was not mutagenic, but the coal-tar based sealcoat products were. The zebrafish developmental toxicity tests suggested that fractions where NPAHs and OPAHs eluted have the most significant adverse effects.

中文翻译：

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路面密封漆产品中未取代的PAHs和新型PAH衍生物的鉴定和毒理学评估。

路面密封涂料产品包含高浓度的未取代多环芳烃（PAH），但是在不包含PAH衍生物的情况下，对潜在毒理学影响的评估受到限制。这项研究确定了23种未取代的PAHs，11种高分子量PAHs（MW302-PAHs）和56种PAH衍生物的浓度，包括10种甲基PAHs（MPAHs），10种杂环PAHs（Hetero-PAHs），26种硝化PAHs （NPAHs）和10种含氧的PAHs（OPAHs）用于煤焦油和沥青密封漆产品和时间点废料。包含MW302-PAHs会使煤焦油基产品的计算出的苯并[a] py致癌当量（B [a] Peq）浓度增加4.1-38.7％。施用后测定某些NPAH和OPAH浓度的增加，提示未取代的PAHs发生光化学转化的可能性。Ames测定表明，沥青基产品不是诱变的，但煤焦油基密封涂层产品是诱变的。斑马鱼发育毒性测试表明，洗脱出NPAH和OPAH的级分具有最明显的不利影响。