Three hexacoordinated octahedral nickel(II) complexes, [Ni(sal-L-phe)(phen)(CH₃OH)]⋅CH₃OH (1), [Ni(naph-L-phe)(phen)(CH₃OH)] (2), and [Ni(o-van-L-phe)(phen)(CH₃OH)]⋅5CH₃OH (3) (sal-L-phe = a Schiff base derived from salicylaldehyde and L-phenylalanine, naph-L-phe = a Schiff base derived from 2-hydroxy-1-naphthaldehyde and L-phenylalanine, o-van-L-phe = a Schiff base derived from o-vanillin and L-phenylalanine, and phen = 1,10-phenanthroline), have been synthesized and characterized by elemental analysis, IR spectra, and single-crystal X-ray diffraction. The interactions of these complexes with CT-DNA were studied by UV-Vis absorption spectroscopy, fluorescence spectroscopy, circular dichroism spectroscopy, and viscosity measurements. The binding constant (K_b) values of 1.82 × 10⁴ M⁻¹ for 1, 1.96 × 10⁴ M⁻¹ for 2, and 2.02 × 10⁴ M⁻¹ for 3 suggest that each of these complexes could bind with DNA in a moderate intercalative mode. Complex 3 exhibited a stronger interaction with CT-DNA than complexes 1 and 2. In addition, the superoxide scavenging activity of these complexes was investigated by the nitrotetrazolium blue chloride (NBT) light reduction method, and the results showed that they exhibited a significant superoxide scavenging activity with the IC₅₀ values of 4.4 × 10⁻⁵ M for complex 1, 5.6 × 10⁻⁵ M for complex 2, and 3.1 × 10⁻⁵ M for complex 3, respectively.

中文翻译：

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三种含有L-苯丙氨酸席夫碱和1,10-菲咯啉的镍（II）配合物的合成，结构，DNA相互作用和SOD活性。

三种六配位八面体镍（II）配合物，[Ni（sal-L-phe）（phen）（CH ₃ OH）]·CH ₃ OH（1），[Ni（naph-L-phe）（phen）（CH _3） OH）]（2）和[镍（ø -van-L-PHE）（phen）的（CH ₃ OH）]⋅5CH ₃ OH（3）（SAL-L-Phe =苯席夫碱从水杨醛和L衍生-苯基丙氨酸，萘-L-phe =衍生自2-羟基-1-萘醛和L-苯丙氨酸的席夫碱，o -van-L-phe =衍生自o的席夫碱-香兰素和L-苯丙氨酸，和phen = 1,10-菲咯啉），已经合成并通过元素分析，红外光谱和单晶X射线衍射表征。通过UV-Vis吸收光谱，荧光光谱，圆二色光谱和粘度测量研究了这些络合物与CT-DNA的相互作用。结合常数（ķ _b）的1.82×10的值⁴ 中号^-1为1，1.96×10 ⁴ 中号^-1为2，和2.02×10 ⁴ 中号^-1为3表明，这些配合物可以与DNA结合在适度的插入模式。复杂的3与复合物1和2相比，与CT-DNA的相互作用更强。另外，通过氯化硝基四氮唑蓝（NBT）光还原法研究了这些配合物的超氧化物清除活性，结果表明它们显示出显着的超氧化物清除活性，IC ₅₀值为4.4×10 ^-5  M 1， 对于复合物2分别为5.6×10 ^-5 M和 对于复合物3而言为3.1×10 ^-5M。