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Asthma Endotyping and Biomarkers in Childhood Asthma.
Pediatric Allergy, Immunology, and Pulmonology ( IF 0.9 ) Pub Date : 2018-08-03 , DOI: 10.1089/ped.2018.0886
Amelia Licari 1 , Riccardo Castagnoli 1 , Ilaria Brambilla 1 , Alessia Marseglia 1 , Maria Angela Tosca 2 , Gian Luigi Marseglia 1 , Giorgio Ciprandi 3
Affiliation  

Childhood asthma represents a heterogeneous challenging disease, in particular in its severe forms. The identification of different asthma phenotypes has stimulated research in underlying molecular mechanisms, such as the endotypes, and paved the way to the search for related specific biomarkers, which may guide diagnosis, management, and predict response to treatment. A limited number of biomarkers are currently available in clinical practice in the pediatric population, mostly reflecting type 2-high airway inflammation. The identification of biomarkers of childhood asthma is an active area of research that holds a potential great clinical utility and may represent a step forward toward tailored management and therapy: the so-called Precision Medicine. The aim of the present review is to provide an updated overview of asthma endotyping, mostly focusing on novel noninvasive biomarkers in childhood asthma.

中文翻译:

儿童哮喘的哮喘分型和生物标志物。

儿童哮喘代表了一种异质性挑战性疾病,尤其是其严重形式。对不同哮喘表型的鉴定刺激了对内在分子机制如内在型的研究,并为寻找相关的特定生物标志物铺平了道路,这些标志物可以指导诊断,治疗和预测对治疗的反应。目前在临床实践中,在儿科人群中可使用的生物标志物数量有限,主要反映了2型高气道炎症。儿童哮喘生物标志物的鉴定是一个活跃的研究领域,具有潜在的巨大临床实用性,并且可能代表着朝着量身定制的管理和治疗迈出的一步:所谓的精准医学。本评价的目的是提供哮喘内窥镜检查的最新概述,
更新日期:2019-11-01
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