The Warburg effect is one of the hallmarks of cancer cells, characterized by enhanced aerobic glycolysis. Despite intense research efforts, its functional relevance or biological significance to facilitate tumor progression is still debatable. Hence the question persists when and how the Warburg effect contributes to carcinogenesis. Especially, the role of metabolic changes at a very early stage of tumorigenesis has received relatively little attention, and how aerobic glycolysis impacts tumor incidence remains largely unknown. Here we discuss a novel paradigm for the effect of the Warburg effect that provides a suppressive role in oncogenesis.Key words: Warburg effect, aerobic glycolysis, cell competition, EDAC.

中文翻译：

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Warburg效应在转化细胞出现时的抗肿瘤作用。

沃堡效应是癌细胞的标志之一，其特征是有氧糖酵解增强。尽管进行了深入的研究，但其功能相关性或促进肿瘤进展的生物学意义仍然值得商bat。因此，沃伯格效应何时以及如何促进癌变仍然存在问题。尤其是，在肿瘤发生的非常早期阶段，代谢变化的作用就很少受到关注，而且有氧糖酵解如何影响肿瘤发生率仍是未知之数。在这里，我们讨论了对Warburg效应的影响的新范式，该范式在肿瘤发生中起抑制作用。关键词：Warburg效应，有氧糖酵解，细胞竞争，EDAC。