N-halamine-based interpenetrating polymer networks were developed as a simple and effective strategy in the preparation of antimicrobial polymers. An N-halamine monomer, N-chloro-2, 2, 6, 6-tetramethyl-4-piperidyl methacrylate, was incorporated into polyurethane in the presence of a cross-linker and an initiator. Post-polymerization of the monomers led to the formation of polyurethane/N-halamine semi-interpenetrating polymer networks. The presence of N-halamines in the semi-interpenetrating polymer networks was confirmed by attenuated total reflectance infrared, water contact angle, and energy-dispersive X-ray spectroscopy analysis. The N-halamine contents in the semi-interpenetrating polymer networks could be readily controlled by changing reaction conditions. The distribution of active chlorines within the semi-interpenetrating polymer networks was characterized with energy-dispersive X-ray spectroscopy. Contact mode antimicrobial tests, zone of inhibition studies, and scanning electron microscopy observations showed that the semi-interpenetrating polymer networks had potent antimicrobial and antifouling effects against both Gram-positive and Gram-negative bacteria. Release tests demonstrated the outstanding stability of the N-halamine structures in the new semi-interpenetrating polymer networks.

中文翻译：

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用聚氨酯/N-卤胺半互穿聚合物网络控制细菌污染

基于 N-卤胺的互穿聚合物网络被开发为制备抗菌聚合物的一种简单有效的策略。在交联剂和引发剂的存在下，将 N-卤胺单体、N-氯-2, 2, 6, 6-四甲基-4-哌啶基甲基丙烯酸酯结合到聚氨酯中。单体的后聚合导致聚氨酯/N-卤胺半互穿聚合物网络的形成。通过衰减全反射红外、水接触角和能量色散 X 射线光谱分析证实了半互穿聚合物网络中 N-卤胺的存在。通过改变反应条件可以容易地控制半互穿聚合物网络中的 N-卤胺含量。活性氯在半互穿聚合物网络中的分布用能量色散 X 射线光谱法表征。接触模式抗菌试验、抑菌圈研究和扫描电子显微镜观察表明，半互穿聚合物网络对革兰氏阳性菌和革兰氏阴性菌均具有有效的抗菌和防污作用。释放测试证明了新型半互穿聚合物网络中 N-卤胺结构的出色稳定性。扫描电子显微镜观察表明，半互穿聚合物网络对革兰氏阳性菌和革兰氏阴性菌均具有有效的抗菌和防污作用。释放测试证明了新型半互穿聚合物网络中 N-卤胺结构的出色稳定性。扫描电子显微镜观察表明，半互穿聚合物网络对革兰氏阳性菌和革兰氏阴性菌均具有有效的抗菌和防污作用。释放测试证明了新型半互穿聚合物网络中 N-卤胺结构的出色稳定性。