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The small peptide world in long noncoding RNAs.
Briefings in Bioinformatics ( IF 6.8 ) Pub Date : 2019-06-03 , DOI: 10.1093/bib/bby055
Seo-Won Choi 1 , Hyun-Woo Kim 1 , Jin-Wu Nam 1
Affiliation  

Long noncoding RNAs (lncRNAs) are a group of transcripts that are longer than 200 nucleotides (nt) without coding potential. Over the past decade, tens of thousands of novel lncRNAs have been annotated in animal and plant genomes because of advanced high-throughput RNA sequencing technologies and with the aid of coding transcript classifiers. Further, a considerable number of reports have revealed the existence of stable, functional small peptides (also known as micropeptides), translated from lncRNAs. In this review, we discuss the methods of lncRNA classification, the investigations regarding their coding potential and the functional significance of the peptides they encode.

中文翻译:

长非编码RNA中的小肽世界。

长非编码RNA(lncRNA)是一组超过200个核苷酸(nt)且无编码潜能的转录物。在过去的十年中,由于先进的高通量RNA测序技术并借助编码转录物分类器,在动植物基因组中已注解了成千上万种新颖的lncRNA。此外,大量报告揭示了从lncRNA转换而来的稳定的功能性小肽(也称为微肽)的存在。在这篇综述中,我们讨论了lncRNA分类的方法,有关其编码潜力和它们编码的肽的功能意义的研究。
更新日期:2020-04-17
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