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Comparative Secretome Profiling and Mutant Protein Identification in Metastatic Prostate Cancer Cells by Quantitative Mass Spectrometry-based Proteomics.
Cancer Genomics & Proteomics ( IF 2.5 ) Pub Date : 2018-7-7 , DOI: 10.21873/cgp.20086
Oh Kwang Kwon 1 , Ju Mi Jeon 1 , Eunji Sung 1 , Ann-Yea Na 1 , Sun Joo Kim 1 , Sangkyu Lee 2
Affiliation  

Secreted proteins play an important role in promoting cancer (PCa) cell migration and invasion. Proteogenomics helps elucidate the mechanism of diseases, discover therapeutic targets, and generate biomarkers for diagnosis through protein variations.

中文翻译:

通过基于质谱的定量蛋白质组学比较转移性前列腺癌细胞中的分泌蛋白分析和突变蛋白鉴定。

分泌的蛋白质在促进癌细胞(PCa)迁移和侵袭中起重要作用。蛋白质组学有助于阐明疾病的机制,发现治疗靶标,并通过蛋白质变异产生用于诊断的生物标志物。
更新日期:2020-08-21
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