Laminin α1 orchestrates VEGFA functions in the ecosystem of colorectal carcinoma,Biology of the Cell

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Laminin α1 orchestrates VEGFA functions in the ecosystem of colorectal carcinoma
Biology of the Cell ( IF 2.4 ) Pub Date : 2018-07-02 , DOI: 10.1111/boc.201800007
Elmina Mammadova-Bach _{1,

2,

3,

4,

5} , Tristan Rupp _{1,

2,

3,

4} , Caroline Spenlé _{1,

2,

3,

4} , Ivo Jivkov _{1,

2,

3,

4} , Pattabhiraman Shankaranarayanan _{1,

2,

3,

4} , Annick Klein _{1,

2,

3,

4} , Laura Pisarsky _{1,

2,

3,

4,

6} , Agnès Méchine-Neuville ₇ , Gérard Cremel _{1,

2,

3,

4} , Michèle Kedinger _{1,

2,

3,

4} , Olivier De Wever ₈ , Noona Ambartsumian ₉ , Sylvie Robine ₁₀ , Erwan Pencreach _{11,

12} , Dominique Guenot ₁₁ , Patricia Simon-Assmann _{1,

2,

3,

4} , Jacky G Goetz _{1,

2,

3,

4} , Gertraud Orend _{1,

2,

3,

4} , Olivier Lefebvre _{1,

2,

3,

4}

Affiliation

Inserm U1109, MN3T, Strasbourg, F-67200, France.
Université de Strasbourg, Strasbourg, F-67000, France.
LabEx Medalis, Université de Strasbourg, Strasbourg, F-67000, France.
Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, F-67000, France.
Inserm UMR-S 949, Etablissement Français du Sang-Alsace, Strasbourg, F-67065, France.
Public Health Sciences Division/Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, U.S.A.
Department of Anatomy and Pathology, CHRU Hautepierre, Strasbourg, F-67200, France.
Laboratory of Experimental Cancer Research, Department of Radiotherapy and Nuclear Medicine, Ghent University Hospital, Ghent, 9000, Belgium.
Institut for Cancer Biology, Copenhagen, DK-2100, Denmark.
Institut Curie, Paris, F-75248, France.
EA 3430, Université de Strasbourg, Strasbourg, F-67000, France.
Plateforme de Génétique Moléculaire des Cancers, Hôpitaux Universitaires de Strasbourg, Strasbourg, F-67098, France.

Tumor stroma remodeling is a key feature of malignant tumors and can promote cancer progression. Laminins are major constituents of basement membranes that physically separate the epithelium from the underlying stroma.

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