Emerging technologies are now giving us unprecedented access to manipulate brain circuits, shedding new light on treatments for amblyopia. This research is identifying key circuit elements that control brain plasticity and highlight potential therapeutic targets to promote rewiring in the visual system during and beyond early life. Here, we explore how such recent advancements may guide future pharmacological, genetic, and behavioral approaches to treat amblyopia. We will discuss how animal research, which allows us to probe and tap into the underlying circuit and synaptic mechanisms, should best be used to guide therapeutic strategies. Uncovering cellular and molecular pathways that can be safely targeted to promote recovery may pave the way for effective new amblyopia treatments across the lifespan.

中文翻译：

---

弱视：新的分子/药理学和环境方法

新兴技术现在为我们提供了前所未有的途径来操纵大脑回路，为弱视的治疗提供了新的思路。这项研究正在确定控制大脑可塑性的关键电路元件，并突出潜在的治疗目标，以促进生命早期和之后视觉系统的重新布线。在这里，我们探讨了这些最新进展如何指导未来治疗弱视的药理学、遗传和行为方法。我们将讨论如何最好地利用动物研究来指导治疗策略，这使我们能够探索和利用潜在的电路和突触机制。发现可以安全地靶向促进康复的细胞和分子途径可能为在整个生命周期内进行有效的新弱视治疗铺平道路。