Abstract Hyperspectral imaging (HSI) technologies have been used extensively in medical research, targeting various biological phenomena and multiple tissue types. Their high spectral resolution over a wide range of wavelengths enables acquisition of spatial information corresponding to different light-interacting biological compounds. This review focuses on the application of HSI to monitor brain tissue metabolism and hemodynamics in life sciences. Different approaches involving HSI have been investigated to assess and quantify cerebral activity, mainly focusing on: (1) mapping tissue oxygen delivery through measurement of changes in oxygenated (HbO2) and deoxygenated (HHb) hemoglobin; and (2) the assessment of the cerebral metabolic rate of oxygen (CMRO2) to estimate oxygen consumption by brain tissue. Finally, we introduce future perspectives of HSI of brain metabolism, including its potential use for imaging optical signals from molecules directly involved in cellular energy production. HSI solutions can provide remarkable insight in understanding cerebral tissue metabolism and oxygenation, aiding investigation on brain tissue physiological processes.

中文翻译：

---

用于脑组织代谢和血流动力学监测的高光谱成像解决方案：过去、当前和未来的发展


摘要 高光谱成像（HSI）技术已广泛应用于医学研究，针对各种生物现象和多种组织类型。它们在广泛的波长范围内具有高光谱分辨率，能够采集与不同光相互作用的生物化合物相对应的空间信息。本综述重点关注 HSI 在生命科学中监测脑组织代谢和血流动力学的应用。人们已经研究了涉及 HSI 的不同方法来评估和量化大脑活动，主要集中在：（1）通过测量含氧（HbO2）和脱氧（HHb）血红蛋白的变化来绘制组织氧输送图； (2) 评估脑氧代谢率 (CMRO2)，以估计脑组织的耗氧量。最后，我们介绍了 HSI 对大脑代谢的未来前景，包括其在直接参与细胞能量产生的分子的光学信号成像方面的潜在用途。 HSI 解决方案可以为了解脑组织代谢和氧合提供卓越的见解，有助于研究脑组织的生理过程。