Liver sinusoidal endothelial cells (LSECs) possess fenestrae, open transcellular pores with an average diameter of 100 nm. These fenestrae allow for the exchange between blood and hepatocytes. Alterations in their number or diameter in liver diseases have important implications for hepatic microcirculation and function. Although decades of studies, fenestrae are still observed into fixed cells and we have poor knowledge of their dynamics.

中文翻译：

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STED 显微镜：肝窦内皮窗孔分析的简化方法

肝窦内皮细胞 (LSEC) 具有平均直径为 100 nm 的窗孔、开放的跨细胞孔。这些窗孔允许血液和肝细胞之间的交换。肝脏疾病中它们的数量或直径的变化对肝脏微循环和功能具有重要意义。尽管进行了数十年的研究，但仍然在固定细胞中观察到窗孔，我们对其动力学知之甚少。