Acromegaly is a rare endocrine disorder that carries a significant burden of cardiovascular morbidity and mortality. Abnormalities of the growth hormone/insulin-like growth factor-1 axis in acromegaly lead to the characteristic cardiovascular manifestations of this disease. One hallmark feature of the disease is acromegalic cardiomyopathy, a syndrome of progressive cardiac dysfunction characterized by left ventricular hypertrophy, diastolic dysfunction, and combined systolic and diastolic dysfunction in the very advanced stage. In this article, we review the current concepts regarding the pathophysiology of acromegalic cardiomyopathy and discuss the various risk factors for its development. We also explore the question of whether the alterations in cardiac function are reversible with successful biochemical control of growth hormone excess either medically or surgically.

中文翻译：

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肢端肥大性心肌病：危险因素，临床表现和治疗选择的概述。

肢端肥大症是一种罕见的内分泌疾病，它会给心血管疾病的发病率和死亡率带来重大负担。肢端肥大症中生长激素/胰岛素样生长因子-1轴异常导致该疾病的特征性心血管表现。该疾病的一个标志性特征是肢端肥大性心肌病，这是一种进行性心功能不全的综合征，其特征在于左心室肥大，舒张功能不全，以及处于晚期的收缩和舒张功能不全合并在一起。在本文中，我们回顾了有关肢端肥大性心肌病的病理生理学的当前概念，并讨论了其发展的各种危险因素。