Objective: The purpose of this study was to investigate the effects of chromium picolinate (CrPic) supplementation associated with aerobic exercise using measures of oxidative stress in rats exposed to air pollution.

Methods: Sixty-one male Wistar rats were divided into eight groups: residual oil fly ash (ROFA) exposure and sedentary (ROFA-SED); ROFA exposure, sedentary and supplemented (ROFA-SED-CrPic); ROFA exposure and trained (ROFA-AT); ROFA exposure, supplemented and trained (ROFA-AT-CrPic); sedentary (Sal-SED); sedentary and supplemented (Sal-SED-CrPic); trained (Sal-AT); and supplemented and trained (Sal-AT-CrPic). Rats exposed to ROFA (air pollution) received 50 µg of ROFA daily via intranasal instillation. Supplemented rats received CrPic (1 mg/kg/day) daily by oral gavage. Exercise training was performed on a rat treadmill (5×/week). Oxidative parameters were evaluated at the end of protocols.

Results: Trained groups demonstrated lower gain of body mass (P < .001) and increased exercise tolerance (P < .0001). In the gastrocnemius, trained groups demonstrated increased SOD activity (P < .0001) and decrease levels of TBARS (P = .0014), although CAT activity did not differ among groups (P = .4487).

Conclusion: Air pollution exposure did not lead to alterations in oxidative markers in lungs and heart, and exercise training was responsible for decreasing oxidative stress of the gastrocnemius.

目的：本研究的目的是通过测量暴露于空气污染的大鼠中的氧化应激，研究补充有氧运动与吡啶甲酸铬（CrPic）的效果。

方法：将61只雄性Wistar大鼠分为八组：残余油粉煤灰（ROFA）暴露和久坐（ROFA-SED）。久坐和补充的ROFA暴露（ROFA-SED-CrPic）；ROFA接触和培训（ROFA-AT）；ROFA暴露，补充和培训（ROFA-AT-CrPic）；久坐（Sal-SED）; 久坐和补充（Sal-SED-CrPic）；训练有素的（Sal-AT）；并进行了补充和培训（Sal-AT-CrPic）。暴露于ROFA（空气污染）的大鼠每天通过鼻内滴注接受50 µg ROFA。补充的大鼠每天通过管饲法接受CrPic（1 mg / kg /天）。在大鼠跑步机上进行运动训练（5次/周）。在方案结束时评估氧化参数。

结果：训练有素的组显示出较低的体重增加（P  <.001）和增强的运动耐力（P  <.0001）。在腓肠肌中，训练有素的组表现出SOD活性增加（P  <.0001）和TBARS降低（P  = .0014），尽管各组之间的CAT活性没有差异（P  = .4487）。

结论：暴露于空气污染不会导致肺和心脏的氧化标记改变，而运动训练可减轻腓肠肌的氧化应激。