Background

Cytokine genes, including interleukin-10 (IL-10), are known to play important roles in the pathogenesis of juvenile idiopathic arthritis (JIA). This study aims to determine whether the IL-10 polymorphisms confer susceptibility to JIA.

Methods

A meta-analysis was performed on the associations between the IL-10-1082 G/A, -592 C/A, and -819 C/T polymorphisms and JIA. A total number of 7 studies involving 1,785 patients and 6,142 controls were considered in the meta-analysis.

Results

Meta-analysis of the IL-10-592 C/A and -819 C/T polymorphisms showed no association with JIA in the study participants, or in Caucasian or Middle Eastern participants. Meta-analysis of the IL-10-1082 A allele in all study participants, Caucasian and Middle Eastern, showed significant associations with RA (overall ORs were 1.17, 1.15, and 1.41, respectively). Meta-analysis of the AA versus GG genotype of the IL-10-1082 G/A polymorphism revealed significant associations with JIA (OR = 3.66, 95% CI = 1.44-9.29, P = 0.006) in participants from Middle Eastern countries. Additionally, meta-analysis of the GG versus AA+GA genotypes of the IL-10 -1082 G/A polymorphism revealed the GG genotype as the protective factor against JIA in the Middle Eastern subgroup (OR = 0.44, 95% CI = 0.20-0.94, P = 0,04). Moreover, meta-analysis of the IL-10 -1082 A allele in 4 studies on Hardy-Weinberg equilibrium showed a significant association with JIA (OR = 1.17, 95% CI = 1.07-1.28, P = 0.0009). No association was found between the IL-10 (-1082, -819, -592) ACC, ATA, and GCC haplotypes and JIA.

Conclusions

These results suggest that the IL-10-1082 G/A polymorphism confers susceptibility to JIA.

中文翻译：

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白介素10基因多态性与青少年特发性关节炎易感性之间的关联：系统评价和荟萃分析。

背景

已知细胞因子基因，包括白介素10（IL-10）在青少年特发性关节炎（JIA）的发病机理中起重要作用。这项研究旨在确定IL-10多态性是否赋予JIA敏感性。

方法

对所之间的关联进行荟萃分析IL - 10 - 1082 G / A， - 592 C / A，和- 819 C / T多态性与JIA。荟萃分析共考虑了7项研究，涉及1,785例患者和6,142例对照。

结果

荟萃分析的IL-10-592 C / A和- 819 C / T多态性表现出与JIA没有相关的研究参与者，或者在高加索和中东的参与者。对所有研究参与者（高加索人和中东）中IL-10-1082 A等位基因的荟萃分析显示与RA密切相关（总OR分别为1.17、1.15和1.41）。对IL-10-1082的AA和GG基因型的Meta分析G / A多态性显示来自中东国家的参与者与JIA显着相关（OR = 3.66，95％CI = 1.44-9.29，P = 0.006）。此外，对IL-10 -1082 G / A基因多态性的GG与AA + GA基因型的荟萃分析显示，GG基因型是中东亚组中针对JIA的保护因子（OR = 0.44，95％CI = 0.20- 0.94，P = 0.04）。此外，在有关Hardy-Weinberg平衡的4项研究中，对IL-10 -1082 A等位基因的荟萃分析显示与JIA显着相关（OR = 1.17，95％CI = 1.07-1.28，P = 0.0009）。在IL-10（-1082，-819，-592）ACC，ATA和GCC单倍型与JIA之间未发现关联。

结论

这些结果表明IL-10-1082 G / A多态性赋予了对JIA的易感性。