ABSTRACT This study aimed to evaluate femoral perfusion using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for two weeks after the simultaneous initiation of electrical stimulation (ES) and steroid treatment in a steroid-induced osteonecrosis (ON) model. A single dose of methylprednisolone was injected into 14 rabbits. Seven rabbits underwent ES (ES group), and seven rabbits did not (control group). DCE-MRI was performed before steroid administration and 1, 5, 10, and 14 days after steroid administration. Regions of interest were set in the bilateral proximal femora. The enhancement ratio, initial slope, and area under the curve were analyzed. These parameters were evaluated after steroid administration in each group and between the two groups, and the ratios of ON in both groups were compared. In the control group, the minimum values of all parameters decreased significantly after steroid administration (P < 0.05), but in the ES group, the parameters did not decrease. In the ES group, all parameter values were significantly increased on the 10th and 14th days (P < 0.05). All parameter values in the ES group were significantly higher than those in the control group on the 14th day (P < 0.05). In the control group, ON was detected in three of five rabbits (in three of ten femora). In the ES group, ON was not detected. These results suggest that increased femoral blood flow elicited by ES may be related to ON prevention after steroid administration.

中文翻译：

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在骨坏死模型中同时开始电刺激和类固醇治疗后，使用动态对比增强 MRI 评估股骨灌注

摘要 本研究旨在在类固醇诱导的骨坏死 (ON) 模型中同时开始电刺激 (ES) 和类固醇治疗后两周使用动态对比增强磁共振成像 (DCE-MRI) 评估股骨灌注。将单剂量甲泼尼龙注射到 14 只兔子中。七只兔子接受了 ES（ES 组），七只兔子没有（对照组）。DCE-MRI 在类固醇给药前和类固醇给药后 1、5、10 和 14 天进行。感兴趣的区域设置在双侧股骨近端。分析了增强率、初始斜率和曲线下面积。在每组和两组之间在类固醇给药后评估这些参数，并比较两组中ON的比率。在对照组中，类固醇给药后所有参数的最小值显着下降（P < 0.05），但在 ES 组中，参数没有下降。ES组所有参数值在第10天和第14天均显着增加（P < 0.05）。第 14 天 ES 组各项参数值均显着高于对照组（P < 0.05）。在对照组中，五只兔子中的三只（十只股骨中的三只）检测到 ON。在 ES 组中，未检测到 ON。这些结果表明 ES 引起的股骨血流量增加可能与类固醇给药后预防 ON 相关。所有参数值在第 10 天和第 14 天显着增加（P < 0.05）。第 14 天 ES 组各项参数值均显着高于对照组（P < 0.05）。在对照组中，五只兔子中的三只（十只股骨中的三只）检测到 ON。在 ES 组中，未检测到 ON。这些结果表明 ES 引起的股骨血流量增加可能与类固醇给药后预防 ON 相关。所有参数值在第 10 天和第 14 天显着增加（P < 0.05）。第 14 天 ES 组各项参数值均显着高于对照组（P < 0.05）。在对照组中，五只兔子中的三只（十只股骨中的三只）检测到 ON。在 ES 组中，未检测到 ON。这些结果表明 ES 引起的股骨血流量增加可能与类固醇给药后预防 ON 相关。