Up‐regulated Gene clone 7 (URG7) is an ER resident protein, whose expression is up‐regulated in the presence of hepatitis B virus X antigen (HBxAg) during HBV infection. In virus‐infected hepatocytes, URG7 shows an anti‐apoptotic activity due to the PI3K/AKT signalling activation, does not seem to have tumorigenic properties, but it appears to promote the development and progression of fibrosis. However, the molecular mechanisms underlying URG7 activity remain largely unknown.

中文翻译：

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关于 URG7 在细胞内质网应激反应中的功能作用的新见解

上调基因克隆 7 (URG7) 是一种内质网驻留蛋白，在 HBV 感染期间存在乙型肝炎病毒 X 抗原 (HBxAg) 时其表达上调。在病毒感染的肝细胞中，由于 PI3K/AKT 信号激活，URG7 显示出抗凋亡活性，似乎没有致瘤特性，但它似乎促进了纤维化的发展和进展。然而，URG7 活性的分子机制在很大程度上仍然未知。