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Staphylococcal enterotoxin C2 promotes osteogenesis of mesenchymal stem cells and accelerates fracture healing.
Bone & Joint Research ( IF 4.7 ) Pub Date : 2018-04-12 , DOI: 10.1302/2046-3758.72.bjr-2017-0229.r1
T Wu 1 , J Zhang 2 , B Wang 3 , Y Sun 3 , Y Liu 3 , G Li 4
Affiliation  

As one of the heat-stable enterotoxins, Staphylococcal enterotoxin C2 (SEC2) is synthesized by Staphylococcus aureus, which has been proved to inhibit the growth of tumour cells, and is used as an antitumour agent in cancer immunotherapy. Although SEC2 has been reported to promote osteogenic differentiation of human mesenchymal stem cells (MSCs), the in vivo function of SCE2 in animal model remains elusive. The aim of this study was to further elucidate the in vivo effect of SCE2 on fracture healing.

中文翻译:

葡萄球菌肠毒素 C2 促进间充质干细胞的成骨并加速骨折愈合。

葡萄球菌肠毒素C2(SEC2)是一种热稳定性肠毒素,由金黄色葡萄球菌合成,已被证明可抑制肿瘤细胞的生长,在癌症免疫治疗中用作抗肿瘤剂。尽管据报道 SEC2 可促进人间充质干细胞 (MSCs) 的成骨分化,但SCE2 在动物模型中的体内功能仍然难以捉摸。本研究的目的是进一步阐明SCE2 对骨折愈合的体内作用。
更新日期:2020-08-21
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