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Effects of a phosphocitrate analogue on osteophyte, subchondral bone advance, and bone marrow lesions in Hartley guinea pigs.
Bone & Joint Research ( IF 4.7 ) Pub Date : 2018-04-12 , DOI: 10.1302/2046-3758.72.bjr-2017-0253
Y Sun 1 , A J Kiraly 1 , A R Sun 1 , M Cox 1 , D R Mauerhan 1 , E N Hanley 1
Affiliation  

The objectives of this study were: 1) to examine osteophyte formation, subchondral bone advance, and bone marrow lesions (BMLs) in osteoarthritis (OA)-prone Hartley guinea pigs; and 2) to assess the disease-modifying activity of an orally administered phosphocitrate 'analogue', Carolinas Molecule-01 (CM-01).

中文翻译:

磷酸柠檬酸盐类似物对 Hartley 豚鼠骨赘、软骨下骨进展和骨髓损伤的影响。

本研究的目的是:1) 检查易患骨关节炎 (OA) 的 Hartley 豚鼠的骨赘形成、软骨下骨前移和骨髓损伤 (BML);2) 评估口服磷酸柠檬酸盐“类似物”Carolinas Molecule-01 (CM-01) 的疾病缓解活性。
更新日期:2020-08-21
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