Psoriasis is a common, chronic, inflammatory skin disease that affects 2%–4% of the global population. Recent studies have shown that increased oxidative stress (OS) and T-cell abnormalities are central to the pathogenesis of this disease. The resulting reactive oxygen species (ROS) induces proliferation and differentiation of Th17/Th1/Th22 cells and inhibits the anti-inflammatory activities of regulatory T lymphocytes (Treg). Subsequent secretions of inflammatory cytokines, such as interleukin (IL)-17, IL-22, tumor necrosis factor alpha (TNF-α), and interferon-gamma (IFN-γ), and vascular endothelial growth factor (VEGF), stimulate keratinocyte proliferation and angiogenesis.

Proanthocyanidins are a class of flavonoids from plants and fruits, and have various antioxidant, anti-inflammatory, and anti-angiogenic properties. Numerous reports have demonstrated therapeutic effects of proanthocyanidins for various diseases. Among clinical activities, proanthocyanidins suppress cell proliferation, prevent OS, and regulate Th17/Treg cells. Because the pathogenesis of psoriasis involves OS and T cells dysregulation, we reviewed the effects of proanthocyanidins on OS, Th17 and Treg cell activities, and keratinocyte proliferation and angiogenesis. Data from multiple previous studies warrant consideration of proanthocyanidins as a promising strategy for the treatment of psoriasis.

牛皮癣是一种常见的慢性炎症性皮肤病，影响全球 2%–4% 的人口。最近的研究表明，氧化应激 (OS) 增加和 T 细胞异常是这种疾病发病机制的核心。由此产生的活性氧 (ROS) 诱导 Th17/Th1/Th22 细胞增殖和分化，并抑制调节性 T 淋巴细胞 (Treg) 的抗炎活性。随后分泌炎症细胞因子，如白细胞介素 (IL)-17、IL-22、肿瘤坏死因子 α (TNF-α) 和干扰素-γ (IFN-γ) 以及血管内皮生长因子 (VEGF)，刺激角质形成细胞增殖和血管生成。

原花青素是一类来自植物和水果的黄酮类化合物，具有多种抗氧化、抗炎和抗血管生成特性。大量报告证明原花青素对多种疾病有治疗作用。在临床活性中，原花青素可抑制细胞增殖、预防 OS 并调节 Th17/Treg 细胞。由于银屑病的发病机制涉及 OS 和 T 细胞失调，我们综述了原花青素对 OS、Th17 和 Treg 细胞活性以及角质形成细胞增殖和血管生成的影响。先前多项研究的数据证明原花青素是治疗牛皮癣的一种有前途的策略。