The importance of the sulfur-fluorine bond is starting to increase in modern medicinal chemistry literature. This is due to a better understanding of the stability and reactivity of this moiety depending on the various oxidation states of sulfur. Furthermore, several commercial reagents used for mild and selective fluorination of organic molecules are based on the known reactivity of S-F groups. In this review, we will show how these examples are translating into the 18F field, both for use as stable tags in finished radiopharmaceuticals and as mildly reactive fluoride-relay intermediates. Finally, we also discuss current opportunities where examples of non-radioactive S-F applications/chemistry may be translated into future 18F radiochemistry applications.

中文翻译：

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PET放射化学中的硫-氟键。

在现代药物化学文献中，硫-氟键的重要性开始增加。这是由于根据硫的各种氧化态更好地理解了该部分的稳定性和反应性。此外，用于温和且选择性地氟化有机分子的几种商业试剂是基于SF基团的已知反应性。在这篇综述中，我们将展示这些实例如何转化为18F领域，既可以用作成品放射性药物中的稳定标签，也可以用作中等反应性的氟化物中继中间体。最后，我们还讨论了将非放射性SF应用/化学实例转化为未来18F放射化学应用的当前机会。