Abstract Some pH responsive polymeric matrix of Linseed (Linum usitatissimum), L. hydrogel (LSH) was prepared by free radical polymerization using potassium persulfate (KPS) as an initiator, N,N-methylene bisacrylamide (MBA) as a crosslinker, acrylic acid (AA) and methacrylic acid (MAA) as monomers; while ketoprofen was used as a model drug. Different formulations of LSH-co-AA and LSH-co-MAA were formulated by varying the concentration of crosslinker and monomers. Structures obtained were thoroughly characterized using Fourier transforms infrared (FTIR) spectroscopy, XRD analysis and Scanning electron microscopy. Sol-gel fractions, porosity of the materials and ketoprofen loading capacity were also measured. Swelling and in vitro drug release studies were conducted at simulated gastric fluids, i.e., pH 1.2 and 7.4. FTIR evaluation confirmed successful grafting of AA and MAA to LSH backbone. XRD studies showed retention of crystalline structure of ketoprofen in LSH-co-AA and its amorphous dispersion in LSH-co-MAA. Gel content was increased by increasing MBA and monomer content; whereas porosity of hydrogel was increased by increasing monomer concentration and decreased by increasing MBA content. Swelling of copolymer hydrogels was high at pH 7.4 and low at pH 1.2. Ketoprofen release showed an increasing trend by increasing monomer content; however it was decreased with increasing MBA content. Sustained release of ketoprofen was noted from copolymers and release followed Korsmeyer-Peppas model.

中文翻译：

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用于控制递送酮洛芬的 pH 敏感交联亚麻籽多糖-共-丙烯酸/甲基丙烯酸水凝胶的制备和表征

摘要 以过硫酸钾 (KPS) 为引发剂, N,N-亚甲基双丙烯酰胺 (MBA) 为交联剂, 丙烯酸通过自由基聚合制备了亚麻籽 (Linum usitatissimum)、L.水凝胶 (LSH) 的一些 pH 响应聚合物基质。 (AA) 和甲基丙烯酸 (MAA) 作为单体；而酮洛芬被用作模型药物。通过改变交联剂和单体的浓度来配制 LSH-co-AA 和 LSH-co-MAA 的不同配方。使用傅里叶变换红外 (FTIR) 光谱、XRD 分析和扫描电子显微镜对获得的结构进行了彻底表征。还测量了溶胶-凝胶分数、材料的孔隙率和酮洛芬负载能力。在模拟胃液，即pH 1.2 和7.4 下进行膨胀和体外药物释放研究。FTIR 评估证实 AA 和 MAA 成功接枝到 LSH 主链。XRD 研究表明酮洛芬在 LSH-co-AA 中的晶体结构得以保留，而在 LSH-co-MAA 中则为无定形分散体。通过增加 MBA 和单体含量来增加凝胶含量；而水凝胶的孔隙率随着单体浓度的增加而增加，随着 MBA 含量的增加而降低。共聚物水凝胶的溶胀在 pH 7.4 时高，在 pH 1.2 时低。随着单体含量的增加，酮洛芬的释放量呈增加趋势；但随着 MBA 内容的增加而减少。从共聚物中注意到酮洛芬的持续释放，并且释放遵循 Korsmeyer-Peppas 模型。通过增加 MBA 和单体含量来增加凝胶含量；而水凝胶的孔隙率随着单体浓度的增加而增加，随着 MBA 含量的增加而降低。共聚物水凝胶的溶胀在 pH 7.4 时高，在 pH 1.2 时低。随着单体含量的增加，酮洛芬的释放量呈增加趋势；但随着 MBA 内容的增加而减少。从共聚物中注意到酮洛芬的持续释放，并且释放遵循 Korsmeyer-Peppas 模型。通过增加 MBA 和单体含量来增加凝胶含量；而水凝胶的孔隙率随着单体浓度的增加而增加，随着 MBA 含量的增加而降低。共聚物水凝胶的溶胀在 pH 7.4 时高，在 pH 1.2 时低。随着单体含量的增加，酮洛芬的释放量呈增加趋势；但随着 MBA 内容的增加而减少。从共聚物中注意到酮洛芬的持续释放，并且释放遵循 Korsmeyer-Peppas 模型。但随着 MBA 内容的增加而减少。从共聚物中注意到酮洛芬的持续释放，并且释放遵循 Korsmeyer-Peppas 模型。但随着 MBA 内容的增加而减少。从共聚物中注意到酮洛芬的持续释放，并且释放遵循 Korsmeyer-Peppas 模型。