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Seminal plasma adipokines: involvement in human reproductive functions.
European Cytokine Network ( IF 2.8 ) Pub Date : 2018-06-20 , DOI: 10.1684/ecn.2018.0403
Yaelle Elfassy 1 , Chloe McAvoy 2 , Soraya Fellahi 3 , Joëlle Dupont 4 , Bruno Fève 5 , Rachel Levy 1 , Jean-Philippe Bastard 3
Affiliation  

Infertility, which increased worldwide over the past few decades, has recently been linked to obesity prevalence. Adipokines, produced by adipose tissue, could be the link between obesity and infertility. The association between circulating adipokines and female infertility has been extensively studied in the last ten years. However, the male aspect has been less investigated, although some adipokines are present in seminal plasma. We have attempted to analyze published studies that measured seminal plasma adipokines and their relationships with semen parameters. Apart from leptin, other seminal adipokines have rarely been studied. Indeed, leptin seems to have a differential role depending on its concentration in the seminal plasma. Thus, it could have a beneficial effect at lower concentrations but a deleterious effect at higher seminal levels. Although some studies are currently available, the roles of leptin and other adipokines in seminal plasma on sperm parameters and their consequences on male fertility remain to be clarified.

中文翻译:

精浆脂肪因子:参与人类生殖功能。

在过去的几十年中,世界范围内不育症的增加,最近与肥胖症的流行有关。脂肪组织产生的脂肪因子可能是肥胖与不育之间的联系。在过去的十年中,对循环脂肪因子与女性不育症之间的关联进行了广泛的研究。然而,尽管精浆中存在某些脂肪因子,但对男性方面的研究较少。我们试图分析已发表的研究,这些研究测量了精浆中的血浆脂肪因子及其与精液参数的关系。除瘦素外,很少研究其他精子脂肪因子。确实,瘦素似乎具有不同的作用,这取决于其在精浆中的浓度。因此,在较低的浓度下可能有有益的作用,而在较高的精液浓度下可能有有害作用。
更新日期:2018-06-20
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