A method for the asymmetric synthesis of the disaccharide portion of SCH-47554 has been developed in 6 steps. The route is shorter than the reported route to a related disaccharide. The route involves the use of the Noyori reduction to establish the asymmetry of the d- and l-sugar portion of the molecule. Diastereoselective Pd-glycosylation reaction and subsequent post-glycosylation transformation are used to establish the remaining stereocenter.

中文翻译：

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再次对 SCH-47554 的二糖部分进行不对称处理。


已开发出一种分 6 个步骤不对称合成 SCH-47554 二糖部分的方法。该路线比报道的相关二糖路线短。该途径涉及使用 Noyori 还原来建立分子的 d- 和 l- 糖部分的不对称性。非对映选择性 Pd 糖基化反应和随后的糖基化后转化用于建立剩余的立体中心。