The mechanisms underlying motoneuron degeneration in amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder that affects the motor system with progressive paralysis, are complex and not yet fully understood. It is generally agreed that ALS is a multifactorial and multisystem disease due not only possibly to genetic causes but also to other factors like oxidative stress, mitochondrial dysfunction, protein aggregation, RNA dysmetabolism, autophagy, and excitotoxicity glutamate-mediate. Altered oxidative stress biomarker profile has been repeatedly reported in ALS patients, which may suggest that abnormal free radical production is relevant in the ALS pathogenesis. This review aims to investigate how oxidative stress can affect other proposed mechanisms of neurodegeneration in ALS.

中文翻译：

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神经变性的致病机制之间的相互影响：氧化应激在肌萎缩性侧索硬化症中的作用。

肌萎缩性侧索硬化症（ALS）中的运动神经元变性的潜在机制很复杂，目前尚不完全清楚，该疾病是一种以进行性麻痹影响运动系统的神经退行性疾病。人们普遍认为，ALS是一种多因素和多系统疾病，不仅可能是由于遗传原因，还由于其他因素，例如氧化应激，线粒体功能障碍，蛋白质聚集，RNA代谢障碍，自噬和谷氨酸介导的兴奋性毒性。在ALS患者中反复报道了氧化应激生物标志物改变的情况，这可能表明异常的自由基产生与ALS发病机制有关。这篇综述旨在调查氧化应激如何影响ALS中其他拟议的神经退行性机制。