Poly(β amino ester) polymers have received growing attention in the literature, owing to their ease of synthesis, versatile co-monomer selection, and highly tunable degradation kinetics. As such, they have shown extensive potential in many biomedical applications as well. In this work, it is demonstrated for the first time that PβAE polymers containing primary and secondary amine groups can undergo degradation by primary alcohols via transesterification mechanism. While this work emphasizes an important aspect of solvent compatibility of these networks, it also represents an interesting, simple mechanism for post synthesis drug incorporation, with riboflavin conjugation being demonstrated as a model compound.

中文翻译：

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通过酯交换作用降解醇中的聚（β-氨基酯）凝胶：一种将药物与聚合物基质偶联的方法。

聚（β氨基酯）聚合物由于其易于合成，通用的共聚单体选择和高度可调的降解动力学而在文献中受到越来越多的关注。因此，它们在许多生物医学应用中也显示出了巨大的潜力。在这项工作中，首次证明了含有伯胺基和仲胺基的PβAE聚合物可以通过酯交换机制被伯醇降解。尽管这项工作强调了这些网络的溶剂相容性的重要方面，但它也代表了合成后药物掺入的有趣，简单的机制，核黄素结合被证明是模型化合物。