Increased life expectancy, due to the rise in life quality and the decline in mortality rates, is leading to a society in which the population aged 60 and over is growing more rapidly than the entire population. Although various models and model organisms have been employed to investigate the mechanism of aging, induced pluripotent stem cells (iPSCs) are useful candidates to study human aging and age‐related human diseases. This work discusses how iPSCs can be used as an alternative to the model organisms such as yeast, Caenorhabditis elegans, Drosophila melanogaster, or the mouse. The main focus is the reprogramming technology of somatic cells which is thought to provide an important perspective for rejuvenation strategies. The effects and relationships between aging and cell reprogramming are discussed, and studies related to aging and cell reprogramming are critically reviewed. We believe that for future studies, different parameters and detailed quantitative experiments should be performed in order to clearly understand the effect of aging on human cell reprogramming with respect to programming efficiency and differentiation capacity. This way, new insights will be provided to prevent or even reverse the aging process. WIREs Dev Biol 2018, 7:e308. doi: 10.1002/wdev.308

中文翻译：

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细胞重编程：了解衰老机制的新方法。

由于生活质量的提高和死亡率的降低，预期寿命的增加导致了一个社会，其中60岁及以上的人口比整个人口增长更快。尽管已使用各种模型和模型生物来研究衰老的机制，但诱导多能干细胞（iPSC）是研究人类衰老和与年龄有关的人类疾病的有用候选物。这项工作讨论了如何将iPSC用作模型生物的替代品，例如酵母，秀丽隐杆线虫，果蝇（Drosophila melanogaster），或鼠标。主要焦点是体细胞的重编程技术，据认为该技术为复兴策略提供了重要的视角。讨论了衰老和细胞重编程之间的作用和关系，并严格审查了与衰老和细胞重编程有关的研究。我们相信，对于未来的研究，应该执行不同的参数和详细的定量实验，以便就编程效率和分化能力清楚地了解衰老对人细胞重编程的影响。这样，将提供新的见解以防止甚至逆转老化过程。电线发展生物学2018，7：e308。doi：10.1002 / wdev.308