In the present study, we investigated the distribution of CXCL14 immunoreactive endocrine cells and neurons in mouse alimentary tract by immunohistochemistry. CXCL14 immunoreactive endocrine cells were found as closed-type cells in the stomach and open-type cells in the small intestine. The immunostaining of these endocrine cells corresponded with that of the somatostatin-containing endocrine cells. Only a few CXCL14 immunoreactive endocrine cells were seen in the large intestine. CXCL14 immunoreactive fibers were observed in the muscular layer from the stomach to the rectum with most abundance in the rectum. Many CXCL14 immunoreactive fibers were observed in the lamina propria and submucosal layer from the duodenum to the rectum with most abundance in the rectum; these fibers corresponded to the somatostatin-containing nerve fibers. Some CXCL14 immunoreactive neuronal somata that were also immuno-positive for somatostatin, were noted in the submucosal layer of the rectum. However, the remaining parts of the alimentary tract presented with almost negligible immunoreactive somata. The co-localization of CXCL14 and somatostatin suggests that CXCL14 contributes to the function of somatostatin, which include the inhibition of other endocrine and exocrine cells and the enteric nervous systems.

中文翻译：

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CXCL14 样免疫反应性存在于含有生长抑素的内分泌细胞以及小鼠消化道的固有层和粘膜下生长抑素神经系统中。


在本研究中，我们通过免疫组织化学研究了CXCL14免疫反应性内分泌细胞和神经元在小鼠消化道中的分布。 CXCL14免疫反应性内分泌细胞在胃中为封闭型细胞，在小肠中为开放型细胞。这些内分泌细胞的免疫染色与含有生长抑素的内分泌细胞的免疫染色一致。在大肠中仅观察到少量 CXCL14 免疫反应性内分泌细胞。在从胃到直肠的肌肉层中观察到CXCL14免疫反应性纤维，其中直肠中最丰富。从十二指肠到直肠的固有层和粘膜下层观察到许多CXCL14免疫反应性纤维，其中以直肠最多；这些纤维对应于含有生长抑素的神经纤维。在直肠粘膜下层中发现了一些 CXCL14 免疫反应性神经元体，其对生长抑素也呈免疫阳性。然而，消化道的其余部分呈现出几乎可以忽略不计的免疫反应性体细胞。 CXCL14 和生长抑素的共定位表明 CXCL14 有助于生长抑素的功能，包括抑制其他内分泌和外分泌细胞以及肠神经系统。