Background: Cardiovascular disease is the main cause of morbidity and mortality in the world and oxidative stress has been implicated in the pathogenesis. Cardiac rehabilitation in patients with coronary artery disease submitted to coronary artery bypass grafting may prevent cardiovascular events probably through the attenuation of oxidative stress. The aim of this study was to evaluate the benefits of a cardiac rehabilitation program in the control of the systemic oxidative stress.

Methods: The studied population consisted of 40 patients, with chronic stable coronary artery disease submitted to coronary artery bypass grafting, who attended a cardiac rehabilitation program. Biomarkers of oxidative stress were evaluated in the blood of these patients at different moments.

Results: After the onset of cardiac rehabilitation, there was a significant and progressive decrease in thiobarbituric acid reactive substances levels and protein carbonyls, an initial increase and subsequent decrease in superoxide dismutase, catalase and glutathione peroxidase activities. Also, a progressive increase of uric acid, while ferric reducing antioxidant power levels increased only at the end of the cardiac rehabilitation and a tendency to increase of glutathione contents.

Conclusions: The results suggest that regular exercise through a cardiac rehabilitation program can attenuate oxidative stress in chronic coronary artery disease patients submitted to coronary artery bypass grafting.

背景：心血管疾病是世界范围内发病和死亡的主要原因，氧化应激与发病机制有关。接受冠状动脉旁路移植术的冠状动脉疾病患者的心脏康复可能通过减轻氧化应激来预防心血管事件。本研究的目的是评估心脏康复计划在控制全身氧化应激方面的益处。

方法：研究人群包括 40 名接受冠状动脉旁路移植术的慢性稳定性冠状动脉疾病患者，他们参加了心脏康复计划。在不同时刻评估这些患者血液中的氧化应激生物标志物。

结果：心脏康复开始后，硫代巴比妥酸反应物质水平和蛋白质羰基水平显着且进行性下降，超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶活性先上升后下降。此外，尿酸逐步增加，而铁降低抗氧化能力水平仅在心脏康复结束时增加，并且谷胱甘肽含量有增加的趋势。

结论：结果表明，通过心脏康复计划进行定期锻炼可以减轻接受冠状动脉旁路移植术的慢性冠状动脉疾病患者的氧化应激。