Liver injury resulting from exposure to drugs and chemicals is a major health problem. Autophagy is an important factor in a wide range of diseases, such as cancer, liver disease, muscular disorder, neurodegeneration, pathogen infection, and aging, and emerging evidence indicates that autophagy makes a substantial contribution to the pathogenesis of drug- and chemical-induced liver toxicity. In this review, we summarize current knowledge on autophagy triggered by toxicants/toxins, the protective role of autophagy in liver toxicity, and the underlying molecular mechanisms. We also highlight experimental approaches for studying autophagy.

中文翻译：

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药物性肝毒性中的自噬

接触药物和化学品导致的肝损伤是一个主要的健康问题。自噬是癌症、肝病、肌肉疾病、神经退行性疾病、病原体感染和衰老等多种疾病的重要因素，新出现的证据表明自噬对药物和化学诱导的发病机制做出了重大贡献。肝毒性。在这篇综述中，我们总结了目前关于毒物/毒素引发的自噬、自噬在肝毒性中的保护作用以及潜在的分子机制的知识。我们还强调了研究自噬的实验方法。