The clpks18 gene was first cloned and identified in Curvularia lunata. It contains 6571 base pairs (bp) and an 6276 bp open reading frame encoding 2091 amino acids. The ClPKS18 deletion mutant displayed an albino phenotype, and almost lost the ability to product 5-(hydroxymethyl) furan-2-carboxylate (M5HF2C) toxin, implying that clpks18 gene in C. lunata is not only involved in 1,8-dihydroxynaphthalene melanin synthesis, but also relatively associated with M5HF2C toxin biosynthesis of the pathogen. The pathogenicity assays revealed that ΔClPKS18 was impaired in colonizing the maize leaves, which corresponds to the finding that ClPKS18 controls the production of melanin and M5HF2C in C. lunata. Results indicate that ClPKS18 plays a vital role in regulating pathogenicity of in C. lunata.

中文翻译：

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聚酮化合物合成酶ClPKS18参与调节弯孢弯曲菌的营养生长，黑色素和毒素合成以及毒力。

该clpks18基因首次被克隆和鉴定中弯孢菌。它包含6571个碱基对（bp）和6276 bp的开放阅读框，编码2091个氨基酸。所述ClPKS18缺失突变体显示的白化的表型，并且几乎失去的能力产物5-（羟甲基）呋喃-2-羧酸甲酯（M5HF2C）毒素，这意味着clpks18基因中C.孢菌不仅参与在1,8-二羟基萘黑色素合成中，还与M5HF2C毒素的生物合成有关。致病性分析表明，在玉米叶片定殖中，ΔClPKS18受到损害，这与以下发现有关：ClPKS18控制月球梭菌中黑色素和M5HF2C的产生。。结果表明，ClPKS18起着调节的致病性至关重要的作用C.霉。