当前位置: X-MOL 学术Best Pract. Res. Clin. Endocrinol. Metab. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Central and peripheral roles of vasopressin in the circadian defense of body hydration.
Best Practice & Research Clinical Endocrinology & Metabolism ( IF 6.1 ) Pub Date : 2017-12-12 , DOI: 10.1016/j.beem.2017.11.001
Claire Gizowski 1 , Eric Trudel 1 , Charles W Bourque 1
Affiliation  

Vasopressin is a neuropeptide synthesized by specific subsets of neurons within the eye and brain. Studies in rats and mice have shown that vasopressin produced by magnocellular neurosecretory cells (MNCs) that project to the neurohypophysis is released into the blood circulation where it serves as an antidiuretic hormone to promote water reabsorption from the kidney. Moreover vasopressin is a neurotransmitter and neuromodulator that contributes to time-keeping within the master circadian clock (i.e. the suprachiasmatic nucleus, SCN) and is also used as an output signal by SCN neurons to direct centrally mediated circadian rhythms. In this chapter, we review recent cellular and network level studies in rodents that have provided insight into how circadian rhythms in vasopressin mediate changes in water intake behavior and renal water conservation that protect the body against dehydration during sleep.

中文翻译:

加压素在昼夜节律的身体水合作用中的中枢和外围作用。

加压素是由眼睛和大脑内特定神经元子集合成的神经肽。在大鼠和小鼠中进行的研究表明,由投射到神经垂体的大细胞神经分泌细胞(MNC)产生的加压素释放到血液循环中,在血液中用作抗利尿激素,促进肾脏对水的重吸收。此外,加压素是一种神经递质和神经调节剂,有助于在生物钟的主时钟(即视交叉上核,SCN)内保持时间,并且还被SCN神经元用作输出信号来指导中央介导的生物钟节律。在这一章当中,
更新日期:2019-11-01
down
wechat
bug