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Impact of microbial proteases on biotechnological industries.
Biotechnology and Genetic Engineering Reviews ( IF 6.5 ) Pub Date : 2017-12-05 , DOI: 10.1080/02648725.2017.1408256
Goutam Banerjee 1, 2 , Arun Kumar Ray 1
Affiliation  

The demand of enzymes in industrial sectors is increasing rapidly due to their economical and ecological advantages. Micro-organisms produce different types of extracellular enzymes for maintaining their own metabolism, defense, and normal physiological condition. Among several enzymes, proteases have gained special attention in industrial sectors. Several sources of extracellular enzymes are reported by various researchers, but enzymes obtain from microbial sources have high demand in industries due to lower cost, high production rate, availability, stability, and diversity. Among micro-organism, bacteria and fungi are reported to be good sources of different types of proteases such as alkaline protease, cysteine protease, aspartate protease, and metallo protease. In this review, we have summarized the available information about the sources of bacterial and fungal proteases, their purification strategies and their temperature and pH optima. Due to huge competition, companies are trying to reduce their manufacturing cost and that’s why microbial sources of enzymes are important. However, genetically engineered strains or engineered proteases have much more importance over natural isolates/protease in industries due to higher production rate and other advantages. Here we have also summarized the important applications of protease in different industries such as, paper mill, starch degrading sector, food processing factories, and detergent making companies.



中文翻译:

微生物蛋白酶对生物技术产业的影响。

由于其经济和生态优势,工业领域对酶的需求正在迅速增加。微生物产生不同类型的细胞外酶,以维持自身的代谢,防御和正常的生理状况。在几种酶中,蛋白酶已在工业领域受到特别关注。各种研究人员报道了几种细胞外酶的来源,但是由于成本较低,生产率高,可用性,稳定性和多样性,从微生物来源获得的酶在工业上有很高的需求。在微生物中,据报道细菌和真菌是各种类型蛋白酶的良好来源,例如碱性蛋白酶,半胱氨酸蛋白酶,天冬氨酸蛋白酶和金属蛋白酶。在这篇评论中 我们总结了有关细菌和真菌蛋白酶的来源,其纯化策略以及温度和pH最佳值的可用信息。由于竞争激烈,公司正试图降低其制造成本,这就是为什么酶的微生物来源非常重要的原因。然而,由于更高的生产率和其他优点,在工业中,基因工程菌株或工程蛋白酶比天然分离物/蛋白酶具有更大的重要性。在这里,我们还总结了蛋白酶在不同行业中的重要应用,例如造纸厂,淀粉降解行业,食品加工厂和洗涤剂制造公司。公司正在努力降低其制造成本,这就是为什么酶的微生物来源很重要的原因。然而,由于更高的生产率和其他优点,在工业中,基因工程菌株或工程蛋白酶比天然分离物/蛋白酶具有更大的重要性。在这里,我们还总结了蛋白酶在不同行业中的重要应用,例如造纸厂,淀粉降解行业,食品加工厂和洗涤剂制造公司。公司正在努力降低其制造成本,这就是为什么酶的微生物来源很重要的原因。然而,由于更高的生产率和其他优点,在工业中,基因工程菌株或工程蛋白酶比天然分离物/蛋白酶具有更大的重要性。在这里,我们还总结了蛋白酶在不同行业中的重要应用,例如造纸厂,淀粉降解行业,食品加工厂和洗涤剂制造公司。

更新日期:2017-12-05
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