For millennia, in the different cultures all over the world, plants have been extensively used as a source of therapeutic agents with wide-ranging medicinal applications, thus becoming part of a rational clinical and pharmacological investigation over the years. As bioactive molecules, plant-derived polyphenols have been demonstrated to exert many effects on human health by acting on different biological systems, thus their therapeutic potential would represent a novel approach on which natural product-based drug discovery and development could be based in the future. Many reports have provided evidence for the benefits derived from the dietary supplementation of polyphenols in the prevention and treatment of osteoporosis. Polyphenols are able to protect the bone, thanks to their antioxidant properties, as well as their anti-inflammatory actions by involving diverse signaling pathways, thus leading to bone anabolic effects and decreased bone resorption. This review is meant to summarize the research works performed so far, by elucidating the molecular mechanisms of action of polyphenols in a bone regeneration context, aiming at a better understanding of a possible application in the development of medical devices for bone tissue regeneration.

中文翻译：

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多酚诱导的骨合成代谢背后的分子信号机制。

几千年来，在世界各地的不同文化中，植物已被广泛用作具有广泛医学应用的治疗剂来源，从而成为多年来合理的临床和药理学研究的一部分。作为生物活性分子，植物源多酚已被证明通过作用于不同的生物系统对人类健康产生多种影响，因此它们的治疗潜力将代表一种新的方法，未来基于天然产物的药物发现和开发可以以此为基础。许多报告提供了通过膳食补充多酚来预防和治疗骨质疏松症的益处的证据。多酚能够保护骨骼，这要归功于其抗氧化特性，以及通过涉及多种信号通路的抗炎作用，从而导致骨合成代谢作用并减少骨吸收。本综述旨在总结迄今为止所进行的研究工作，阐明多酚在骨再生中的作用分子机制，旨在更好地了解骨组织再生医疗器械开发中的可能应用。