Three novel analogues of salivary peptides as sialorphin (QHNPR) and opiorphin (QRFSR) were synthesized by the solid-phase method. The sequences of these ligands were following: AHNPR, QANPR and QRFPR. The aim of our work was investigation in what way some structural modifications may impact on coordination abilities of studied peptides. In this work we presented the interaction of pentapeptides with copper(II) ions in wide range of pH. To determine the coordination model of ligands there were carried out several studies by spectroscopy (UV–Vis, CD) methods and potentiometric measurements.

中文翻译：

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三种新型唾液肽类似物的配位能力：结构修饰对铜结合的影响。

通过固相方法合成了唾液肽的三个新的类似物，如唾液酸蛋白（QHNPR）和阿片磷脂（QRFSR）。这些配体的序列如下：AHNPR，QANPR和QRFPR。我们工作的目的是研究某些结构修饰可能以何种方式影响所研究肽的配位能力。在这项工作中，我们介绍了五肽在宽pH值范围内与铜离子的相互作用。为了确定配体的配位模型，通过光谱法（UV-Vis，CD）和电位测量法进行了数项研究。