Aging is an agglomerate of biological long-lasting processes that result being inevitable. Main actors in this scenario are both long-term inflammation and oxidative stress. It has been proved that oxidative stress induce alteration in proteins and this fact itself is critically important in the pathophysiological mechanisms leading to diseases typical of aging. Among reactive species, chlorine ones such as hypochlorous acid (HOCl) are cytotoxic oxidants produced by activated neutrophils during chronic inflammation processes. HOCl can also cause damages by reacting with biological molecules. HOCl is generated by myeloperoxidase (MPO) and augmented serum levels of MPO have been described in acute and chronic inflammatory conditions in cardiovascular patients and has been implicated in many inflammatory diseases such as atherosclerosis, neurodegenerative conditions, and some cancers. Due to these data, we decided to conduct an up-to-date review evaluating chlorinative stress effects on every age-related disease linked; potential anti-oxidant countermeasures were also assessed. Results obtained associated HOCl generation to the aging processes and confirmed its connection with diseases like neurodegenerative and cardiovascular pathologies, atherosclerosis and cancer; chlorination was mainly linked to diseases where molecular (protein) alteration constitute the major suspected cause: i.e. inflammation, tissue lesions, DNA damages, apoptosis and oxidative stress itself. According data collected, a healthy lifestyle together with some dietary suggestion and/or the administration of nutracetical antioxidant integrators could balance the effects of chlorinative stress and, in some cases, slow down or prevent the onset of age-releated diseases.

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与年龄有关的疾病中的氯化应激：文献综述。

衰老是生物持久过程的聚集，结果是不可避免的。这种情况下的主要行为者是长期炎症和氧化应激。已经证明氧化应激诱导蛋白质的改变，这一事实本身在导致典型衰老疾病的病理生理机制中至关重要。在反应性物种中，诸如次氯酸（HOCl）之类的氯是慢性炎症过程中活化的中性粒细胞产生的细胞毒性氧化剂。HOCl还可以通过与生物分子反应而造成损害。HOCl是由髓过氧化物酶（MPO）产生的，MPO的血清水平升高已在心血管患者的急性和慢性炎性疾病中进行了描述，并与许多炎性疾病（如动脉粥样硬化，神经退行性疾病和某些癌症。基于这些数据，我们决定进行最新评估，以评估氯化应激对每种与年龄相关的疾病的影响；还评估了潜在的抗氧化对策。获得的结果表明HOCl的产生与衰老过程有关，并证实其与神经退行性疾病和心血管疾病，动脉粥样硬化和癌症等疾病有关；氯化作用主要与分子（蛋白质）改变构成主要可疑原因的疾病有关：即炎症，组织损伤，DNA损伤，细胞凋亡和氧化应激本身。根据收集到的数据，健康的生活方式以及一些饮食建议和/或施用营养性抗氧化剂整合剂可以平衡氯化应激的影响，并且