A quantitative weight of evidence (QWoE) methodology was used to assess higher-tier studies on the effects of imidacloprid (IMI) on honeybees. Assessment endpoints were population size and viability of commercially managed bees and quantity of hive products. A colony-level no-observed-adverse effect concentration (NOAEC) of 25 µg IMI/kg syrup, equivalent to an oral no-observed-adverse-effect-dose of 7.3 ng/bee/d for all responses, was measured. The overall weight of evidence indicates that there is minimal risk to honeybees from exposure to IMI from its use as a seed treatment. Exposures via dusts from currently used seed coatings present a de minimis risk to honeybees when the route of exposure is via uptake in plants that are a source of pollen or nectar for honeybees. There were few higher-tier observational (ecoepidemiological) studies conducted with IMI. Considering all lines of evidence, the quality of the studies included in this analysis was variable, but the results of the studies were consistent and point to the same conclusion - that IMI had no adverse effects on viability of the honeybee colony. Thus, the overall conclusion is that IMI, as currently used as a seed treatment and with good agricultural practices, does not present a significant risk to honeybees at the level of the colony.

中文翻译：

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关于蜜蜂中新烟碱类药物的毒性和风险的更高级研究的证据评估的定量权重。2.吡虫啉。

定量证据权重（QWoE）方法用于评估吡虫啉（IMI）对蜜蜂影响的更高层次的研究。评估的终点是人口规模和商业管理蜜蜂的生存力以及蜂巢产品的数量。测得菌落水平的未观察到的不良反应浓度（NOAEC）为25 µg IMI / kg糖浆，相当于所有反应的口服未观察到的不良反应剂量为7.3 ng / bee / d。总的证据表明，蜜蜂作为种子处理剂暴露在IMI中的风险最小。当暴露途径是通过摄取是蜜蜂花粉或花蜜来源的植物时，通过目前使用的种皮进行的粉尘暴露对蜜蜂的危害最小。使用IMI进行的高层观测（流行病学）研究很少。考虑到所有证据，此分析中包括的研究质量是可变的，但研究结果是一致的，并指向相同的结论-IMI对蜜蜂菌落的生存力没有不利影响。因此，总的结论是，目前用作种子处理并具有良好农业规范的IMI不会在蜂群级别对蜜蜂构成重大风险。